1-[10-[3-(4-propylpiperidin-1-yl)propyl]-9H-acridin-3-yl]ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[10-[3-(4-propylpiperidin-1-yl)propyl]-9H-acridin-3-yl]ethanone
• 化学式: C₂₆H₃₄N₂O
• 分子量: 390.6
• InChiKey: NELMOHXIEAGEQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• IDENTIFICATION OF SMALL MOLECULES THAT FACILITATE THERAPEUTIC EXON SKIPPING
  申请人：Nelson Stanley F.

  公开号：US20140080896A1

  公开（公告）日：2014-03-20

  This invention relates, e.g., to a method for enhancing exon skipping in a pre-mRNA of interest, comprising contacting the pre-mRNA with an effective amount of a small molecule selected from the compounds shown in Table 1, or a pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof, and, optionally, with an antisense oligonucleotide that is specific for a splicing sequence in the pre-mRNA Methods for treating Duchenne muscular dystrophy (DMD) are disclosed.