4-acetyl-2-methoxy-N-methylaniline | 887473-62-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-acetyl-2-methoxy-N-methylaniline
• 英文别名: 1-(3-methoxy-4-(methylamino)phenyl)ethanone；1-[3-methoxy-4-(methylamino)phenyl]ethanone
• CAS: 887473-62-3
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: VUKUVCBUYKQFJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-acetyl-2-methoxy-N-methylaniline 在 硫酸 、 硝酸 作用下， 以 三氟乙酸 为溶剂， 反应 1.0h， 以53%的产率得到N-methyl-2'-methoxy-4',6'-dinitroaniline
  参考文献：
  名称：

  Electrophilic Nitration of Electron-Rich Acetophenones

  摘要：

  It is demonstrated that electron-rich disubstituted acetophenones react according to various electrophilic nitration conditions that generally lead to ipso substitution accompanying the conventional reaction. The hydroxy substituent does not seem prone to favor such behaviour.

  DOI：

  10.1007/s00706-005-0346-3
• 作为产物：
  描述：

  4-ethanoyl-2-methoxyphenyl methanesulfonate 、 甲胺 在 potassium phosphate 、 bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)] 、 N-[2-二(1-金刚烷)磷苯基]吗啉 作用下， 以 1,4-二氧六环 、 叔丁醇 为溶剂， 以66%的产率得到4-acetyl-2-methoxy-N-methylaniline
  参考文献：
  名称：

  应对甲磺酸烷基酯的钯催化交叉偶联中的挑战：酮和伯烷基胺的单芳基化

  摘要：

  甲基（甲酸酯）的Mor（DalPhos）：描述了使用甲磺酸甲磺酸酯偶合伙伴进行酮单α-芳基化和脂肪族伯胺单芳基化的第一个实例。与二烷基酮，伯胺和仲胺以及否则具有挑战性的偶联伙伴丙酮和甲胺一起使用了一系列官能化的甲磺酸烷基酯。Ad =金刚烷基。

  DOI：

  10.1002/anie.201303305

文献信息

• CATALYTIC PROCESS FOR CONVERSION OF BIOMASS INTO HYDROCARBON FUELS
  申请人：on behalf of the University of Nevada, Reno Board of Regents of the Nevada System of Higher Education,

  公开号：US20130079566A1

  公开（公告）日：2013-03-28

  A process for the conversion of lignocellulosic biomass to hydrocarbons is provided. The biomass is subjected to aqueous phase partial oxidation (APPO) in the presence of a heterogeneous oxidation catalyst to selectively provide one or more carboxylic acids in good yields. The carboxylic acids are further upgraded to hydrocarbons in the presence of one or more catalysts, which are capable of catalyzing a ketonization reaction, an aldol condensation reaction, a hydrodeoxygenation reaction, or combinations thereof, and then separating out the hydrocarbons from the one or more catalysts.
• Addressing Challenges in Palladium-Catalyzed Cross-Couplings of Aryl Mesylates: Monoarylation of Ketones and Primary Alkyl Amines
  作者：Pamela G. Alsabeh、Mark Stradiotto

  DOI：10.1002/anie.201303305

  日期：2013.7.8

  Mor(DalPhos) for Me(sylates): Described are the first examples of ketone mono‐α‐arylation and primary aliphatic amine monoarylation employing aryl methanesulfonate coupling partners. A range of functionalized aryl mesylates were employed with dialkyl ketones, and also with primary and secondary amines as well as the otherwise challenging coupling partners acetone and methylamine. Ad=adamantyl.

  甲基（甲酸酯）的Mor（DalPhos）：描述了使用甲磺酸甲磺酸酯偶合伙伴进行酮单α-芳基化和脂肪族伯胺单芳基化的第一个实例。与二烷基酮，伯胺和仲胺以及否则具有挑战性的偶联伙伴丙酮和甲胺一起使用了一系列官能化的甲磺酸烷基酯。Ad =金刚烷基。
• Electrophilic Nitration of Electron-Rich Acetophenones
  作者：Natacha Malecki、Pascal Carato、Raymond Houssin、Philippe Cotelle、Jean-Pierre Hénichart

  DOI：10.1007/s00706-005-0346-3

  日期：2005.9

  It is demonstrated that electron-rich disubstituted acetophenones react according to various electrophilic nitration conditions that generally lead to ipso substitution accompanying the conventional reaction. The hydroxy substituent does not seem prone to favor such behaviour.