5-溴-4-(叔丁基)-1,3-噻唑-2-胺 | 82202-32-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-溴-4-(叔丁基)-1,3-噻唑-2-胺
• 中文别名: 2-氨基-4-叔丁基-5-溴噻唑
• 英文名称: 2-amino-5-bromo-4-t-butylthiazole
• 英文别名: 5-bromo-4-tert-butylthiazol-2-amine；2-amino-5-bromo-4-[(1,1-dimethyl)ethyl]thiazole；5-bromo-4-tert-butyl-1,3-thiazol-2-amine
• CAS: 82202-32-2
• 化学式: C₇H₁₁BrN₂S
• 分子量: 235.148
• InChiKey: ACKLPWWFGUPXSM-UHFFFAOYSA-N

物化性质

• 熔点：
  93-94 °C
• 沸点：
  304.9±22.0 °C(Predicted)
• 密度：
  1.494±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2934100090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Amino-5-bromo-4-t-butylthiazole
Synonyms: 5-Bromo-4-tert-butylthiazol-2-amine

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Amino-5-bromo-4-t-butylthiazole
CAS number: 82202-32-2

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C7H11BrN2S
Molecular weight: 235.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide, sulfur oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  5-溴-4-(叔丁基)-1,3-噻唑-2-胺 在 sodium acetate 、 potassium carbonate 、 溶剂黄146 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 19.5h， 生成 (2E,5E)-2-[(5-bromo-4-tert-butylthiazol-2-yl)imino]-5-(3-nitrobenzylidene)thiazolin-4-one
  参考文献：
  名称：

  2-[(5-卤噻唑-2-基)亚氨基]-5-亚苄基噻唑 啉酮及其制备方法与应用

  摘要：

  本发明涉及化学结构式Ⅰ、Ⅱ、Ⅲ或Ⅳ所示的2‑[(5‑卤噻唑‑2‑基)亚氨基]‑5‑亚苄基噻唑啉‑4‑酮或其混合物：其中，R1选自：氢、C1～C2烷基、C3～C4直链或支链烷基；X选自：氟、氯、溴或碘；X1～X5选自：氢、C1～C2烷基、C3～C4直链或支链烷基、硝基、氨基或NHCOR，其中R选自：氢、C1～C2烷基、C3～C4直链或C3～C4支链烷基。2‑[(5‑卤噻唑‑2‑基)亚氨基]‑5‑亚苄基噻唑啉‑4‑酮或其混合物在制备神经氨酸酶抑制剂中的应用。

  公开号：

  CN105985298B
• 作为产物：
  描述：

  1-溴频哪酮 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 、 乙醇 为溶剂， 反应 2.5h， 生成 5-溴-4-(叔丁基)-1,3-噻唑-2-胺
  参考文献：
  名称：

  EP1512396

  摘要：

  公开号：

文献信息

• Design, synthesis, and bioassay of 4-thiazolinone derivatives as influenza neuraminidase inhibitors
  作者：Mengwu Xiao、Lvjie Xu、Ding Lin、Wenwen Lian、Manying Cui、Meng Zhang、Xiaowei Yan、Shuishi Li、Jun Zhao、Jiao Ye、Ailin Liu、Aixi Hu

  DOI：10.1016/j.ejmech.2021.113161

  日期：2021.3

  A series of 4-thiazolinone derivatives (D1-D58) were designed and synthesized. All of the derivatives were evaluated in vitro for neuraminidase (NA) inhibitory activities against influenza virus A (H1N1), and the inhibitory activities of the five most potent compounds were further evaluated on NA from two different influenza viral subtypes (H3N2 and B), and then their in vitro anti-viral activities

  设计并合成了一系列4-噻唑啉酮衍生物（D1-D58）。在体外评估了所有衍生物对甲型流感病毒（H1N1）的神经氨酸酶（NA）抑制活性，并进一步评估了来自两种不同流感病毒亚型（H3N2和B）的五种最有效化合物对NA的抑制活性，然后使用细胞病变效应（CPE）降低法评估其体外抗病毒活性。结果表明，大多数目标化合物均显示出中等至良好的NA抑制活性。化合物D18对IC 50的抑制作用最强H1N1流感亚型的抗药性值为13.06μM。中所选择的化合物，D18和D41被证明是针对流感病毒 亚型的最有效的抑制剂（IC 50 = 15.00μM和IC 50 = 14.97μM，分别地）。D25是对抗B型流感最有效的化合物（IC 50 = 16.09μM）。此外，在细胞测定中，D41对N1-H275Y变体显示出比参考化合物Oseltamivir和Amantadine低的毒性和更高的效力。结构-活性关系（SAR）分析表明，引入4-CO
• SIP3 antagonists
  申请人：Siena Biotech S.p.A.

  公开号：EP2878339A1

  公开（公告）日：2015-06-03

  The present invention relates to antagonists of the S1P3 receptor formula (A) as herein described and pharmaceutical compositions thereof. The compounds of formula (A) are useful in the preparation of a medicament, in particular for the treatment of Alzheimer's disease.

  本发明涉及如下所述的S1P3受体拮抗剂（A）的公式及其药物组合物。公式（A）的化合物在制备药物方面非常有用，特别是用于治疗阿尔茨海默病。
• INFLAMMATORY CYTOKINE RELEASE INHIBITOR
  申请人：MUTO Susumu

  公开号：US20090192122A2

  公开（公告）日：2009-07-30

  A medicament having inhibitory activity against NF-κB activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.

  一种具有抑制NF-κB激活活性的药物，其包括以下通式(I)所表示的化合物或其药理学上可接受的盐作为活性成分：其中X代表连接基，A代表氢原子或乙酰基，E代表芳基或杂芳基，环X代表芳烃或杂芳烃。
• Nf-kb activation inhibitors
  申请人：Muto Susumu

  公开号：US20060089395A1

  公开（公告）日：2006-04-27

  A medicament having inhibitory activity against NF-κB activation which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is circle around (1)} a fused polycyclic heteroaryl group wherein the ring which binds directly to —CONH— group in the formula (I) is a benzene ring, circle around (2)} unsubstituted thiazol-2-yl group, or circle around (3)} unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —CONH-E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —CONH-E wherein E has the same meaning as that defined above.

  一种药物具有抑制NF-κB活化作用，其包括以下通式(I)所表示的化合物或其药学上可接受的盐、水合物和溶剂化物作为活性成分，其中A代表氢原子或乙酰基，E代表2,5-二取代或3,5-二取代苯基或单环或融合的多环杂环芳基，其可以被取代，但在所述杂环芳基是圆圈(1)}在公式(I)中直接结合—CONH—基团的环为苯环的融合多环杂环芳基，圆圈(2)}未取代的噻唑-2-基团，或者圆圈(3)}未取代的苯并噻唑-2-基团时，不包括该化合物，环Z代表一个芳香烃，除了由公式—O-A所表示的基团外，它也可以有一个或多个取代基，其中A具有与上述定义相同的含义，公式—CONH-E所表示的基团E具有与上述定义相同的含义。
• Inhibitors against the activation of ap-1 and nfat
  申请人：Muto Susumu

  公开号：US20060100257A1

  公开（公告）日：2006-05-11

  A medicament inhibiting the activation of AP-1 which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

  一种药物，抑制AP-1的激活，其活性成分为以下通式（I）所表示的化合物或其药学上可接受的盐、水合物或溶剂化物中所选的一种，其中X代表连接基，其主链中的原子数为2至5（该连接基可以被取代），A代表氢原子或乙酰基，E代表芳基或取代的杂芳基，环Z代表芳烃，除了由式—O-A所表示的基团外，可能还有一个或多个取代基，其中A具有上述定义的相同含义，由式—X-E所表示的基团中，X和E的每一个具有上述定义的相同含义，或者是一个杂芳烃，可能还有一个或多个取代基，其中A具有上述定义的相同含义，由式—X-E所表示的基团中，X和E的每一个具有上述定义的相同含义。