4-[8-(3-azidopropylamino)-6-(1,2-dihydroquinolin-5-yl)-1,7,8,8a-tetrahydroimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylcyclohexa-2,4-diene-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[8-(3-azidopropylamino)-6-(1,2-dihydroquinolin-5-yl)-1,7,8,8a-tetrahydroimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylcyclohexa-2,4-diene-1-carboxamide
• 化学式: C28H33N9O
• 分子量: 511.6
• InChiKey: SGOCTEAJDZWEOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  94.8
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• [EN] COMBINATIONS FOR THE TREATMENT OF CANCER<br/>[FR] COMBINAISONS POUR LE TRAITEMENT DU CANCER
  申请人：BAYER PHARMA AG

  公开号：WO2014020043A1

  公开（公告）日：2014-02-06

  The present invention relates to combinations of at least two compounds A and B, compound A being an inhibitor of Mps-1 kinase, and compound B being an inhibitor of an anti-apoptotic protein of the Bcl-2 family. Another aspect of the present invention relates to the use of such combinations as described supra for the preparation of a medicament for the treatment or prophylaxis of a disease, particurlarly for the treatment of cancer. Another aspect of the present invention relates to the use of an anti-apoptotic protein from the Bcl-2 family as a sensitizer of cells to Mps-1 inhibitors. Another aspect of the present invention relates to the use of the ratio of pro-apoptotic and anti-apoptotic proteins from the Bcl-2 family in a biological sample as a biomarker for a Mps-1 kinase inhibitor treatment.