2,2'-(p-tolylazanediyl)bis(3-phenoxypropan-1-ol) | 1257442-63-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,2'-(p-tolylazanediyl)bis(3-phenoxypropan-1-ol)
• 英文别名: 2-(N-(1-hydroxy-3-phenoxypropan-2-yl)-4-methylanilino)-3-phenoxypropan-1-ol
• CAS: 1257442-63-9
• 化学式: C₂₅H₂₉NO₄
• 分子量: 407.51
• InChiKey: JDAWFUWXGHWXSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯基缩水甘油醚 、 乙烷,三氯氟- 在 二氯二茂钛 作用下， 反应 2.0h， 生成 2,2'-(p-tolylazanediyl)bis(3-phenoxypropan-1-ol) 、 1-(p-toluidino)-3-phenoxypropan-2-ol
  参考文献：
  名称：

  Metallocene catalyzed synthesis of fungistatic vicinal aminoalcohols under solvent free conditions

  摘要：

  Group 4 and 5 metallocenes, Cp2TiCl2, Cp2ZrCl2 and Cp2VCl2, have been evaluated as catalyst in the solvent free, room temperature, preparation of vicinal aminoalcohols. The regioselectivity of the reaction and the fungistatic activity of the prepared compounds against Botrytis cinerea and Colletotrichum gloeosporioides are discussed. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.08.109

文献信息

• Metallocene catalyzed synthesis of fungistatic vicinal aminoalcohols under solvent free conditions
  作者：Gabriela Mancilla、Rosa M. Durán-Patrón、Antonio J. Macías-Sánchez、Isidro G. Collado

  DOI：10.1016/j.bmcl.2010.08.109

  日期：2010.11

  Group 4 and 5 metallocenes, Cp2TiCl2, Cp2ZrCl2 and Cp2VCl2, have been evaluated as catalyst in the solvent free, room temperature, preparation of vicinal aminoalcohols. The regioselectivity of the reaction and the fungistatic activity of the prepared compounds against Botrytis cinerea and Colletotrichum gloeosporioides are discussed. (C) 2010 Elsevier Ltd. All rights reserved.