methyl (Z)-2-cyano-3-[4-(diethylamino)phenyl]prop-2-enoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: methyl (Z)-2-cyano-3-[4-(diethylamino)phenyl]prop-2-enoate
• 化学式: C₁₅H₁₈N₂O₂
• 分子量: 258.32
• InChiKey: DTTSVUFQILNUBD-RAXLEYEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  53.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Local flow and shear stress sensor based on molecular rotors
  申请人：Haidekker A. Mark

  公开号：US20060079001A1

  公开（公告）日：2006-04-13

  A method for detecting local shear stress values using molecular rotors that allows for an extremely sensitive determination of a shear stress field or a flow field, even at very low flow rates. In one embodiment, molecular rotors may be adhered to a fiber optic probe or other solid surface, and the fluorescence emission of those molecular rotors may be probed at a location of the fiber optic probe tip or other solid surface. In another preferred embodiment, rotors may be adhered to another solid surface, such as any glass or polymer substrate that may be pre-functionalized (e.g., quartz, polystyrene or silicate glass) to create a probe that may then be used for in vivo as well as in vitro viscosity measurements. In another embodiment, molecular rotors may be dissolved in a target solution, and emission intensity obtained by one of several techniques.

  一种利用分子转子探测局部剪切应力值的方法，即使在流速很低的情况下，也能极其灵敏地确定剪切应力场或流场。在一个实施方案中，分子转子可以粘附在光纤探针或其他固体表面上，这些分子转子的荧光发射可以在光纤探针尖端或其他固体表面的位置进行探测。在另一个优选的实施方案中，可将转子粘附到另一个固体表面上，如任何可预先功能化的玻璃或聚合物基底（如石英、聚苯乙烯或硅酸盐玻璃），以创建一个探针，然后用于体内和体外粘度测量。在另一个实施方案中，分子转子可以溶解在目标溶液中，并通过多种技术之一获得发射强度。
• Supported molecular biofluid viscosity sensors for in vitro and in vivo use
  申请人：Haidekker A. Mark

  公开号：US20060084177A1

  公开（公告）日：2006-04-20

  A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.

  一种测量粘度的装置和方法，包括将分子转子安装在固体表面，将固体表面暴露在具有待测粘度的流体中，并进行光学测量以确定粘度。固体表面最好是石英、聚苯乙烯或硅酸盐玻璃，如光纤探针或玻璃比色皿。分子转子的类型包括电子供体基团和电子受体基团，这两个基团通过单键相连，从而可以相互旋转，并且在旋转受阻时会发出荧光。
• SUPPORTED MOLECULAR BIOFLUID VISCOSITY SENSORS FOR IN VITRO AND IN VIVO USE
  申请人：Haidekker Mark A.

  公开号：US20090227880A1

  公开（公告）日：2009-09-10

  A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.
• US7517695B2
  申请人：——

  公开号：US7517695B2

  公开（公告）日：2009-04-14
• US7670844B2
  申请人：——

  公开号：US7670844B2

  公开（公告）日：2010-03-02