3-(5-Amino-3-oxofuran-2-yl)-8-benzylsulfonyloxyquinoline-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(5-Amino-3-oxofuran-2-yl)-8-benzylsulfonyloxyquinoline-4-carboxylic acid
• 英文别名: 3-(5-amino-3-oxofuran-2-yl)-8-benzylsulfonyloxyquinoline-4-carboxylic acid
• 化学式: C₂₁H₁₆N₂O₇S
• 分子量: 440.4
• InChiKey: FMHBFCQUHLBKEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  154
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER
  申请人：Rhode Island Hospital

  公开号：EP2897607A2

  公开（公告）日：2015-07-29
• [EN] INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER<br/>[FR] INHIBITEURS DE BÊTA-HYDROLASE POUR LE TRAITEMENT DU CANCER
  申请人：RHODE ISLAND HOSPITAL

  公开号：WO2014047519A2

  公开（公告）日：2014-03-27

  The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2- heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.