2-(1,4-diazepan-1-yl)-3-fluoro-N-(2-methoxyethyl)-5-oxo-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(1,4-diazepan-1-yl)-3-fluoro-N-(2-methoxyethyl)-5-oxo-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide
• 化学式: C₂₃H₂₄FN₅O₃S
• 分子量: 469.5
• InChiKey: HAKCOXFTKXDIPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• QUINOLONE ANALOGS AND METHODS RELATED THERETO
  申请人：Senhwa Biosciences, Inc.

  公开号：EP3092901B1

  公开（公告）日：2020-04-29
• QUINOLONE ANALOGS FOR TREATING AUTOIMMUNE DISEASES
  申请人：Achiron Anat

  公开号：US20140086839A1

  公开（公告）日：2014-03-27

  Provided are methods of treating autoimmune diseases by administering to the subject a therapeutically effective amount of a quinolone compound such as 2-(4-methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide (CX-5461). Also provided are methods of monitoring efficiency of treatment of the quinolone compound by determining the expression level of at least one gene of the RNA polymerase I pathway.