[5-(2,4-Dichloro-3-phenylquinolin-6-yl)-2-(2-fluoropyridin-4-yl)-3-methylimidazol-4-yl]methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [5-(2,4-Dichloro-3-phenylquinolin-6-yl)-2-(2-fluoropyridin-4-yl)-3-methylimidazol-4-yl]methanol
• 英文别名: [5-(2,4-dichloro-3-phenylquinolin-6-yl)-2-(2-fluoropyridin-4-yl)-3-methylimidazol-4-yl]methanol
• 化学式: C₂₅H₁₇Cl₂FN₄O
• 分子量: 479.3
• InChiKey: DEZSBSQGEHZWNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• EP2909193A1
  申请人：——

  公开号：EP2909193A1

  公开（公告）日：2015-08-26
• ORGANIC ELECTROLUMINESCENT DEVICE
  申请人：TAKADA Saki

  公开号：US20100171111A1

  公开（公告）日：2010-07-08

  An organic electroluminescent device is provided and includes: a pair of electrodes; and a light emitting layer between the electrodes. The organic electroluminescent device has a layer containing a compound represented by formula (I). L represents a divalent linking group, Q 1 and Q 2 each independently represents an aromatic or aliphatic heterocycle coordinated to Pt through a nitrogen atom, X 1 represents a 6-membered ring containing one or more nitrogen atoms, Q 1 , Q 2 , and X 1 each independently may have a substituent, X 2 represents a sulfur atom, a phosphorus atom, an oxygen atom, or a nitrogen atom, and X 3 represents a carbon atom, a sulfur atom, or a phosphorus atom.
• [EN] PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T<br/>[FR] MODULATEURS DE ROR-GAMMA-T DE TYPE QUINOLINYLE À LIAISON PHÉNYLE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014062667A1

  公开（公告）日：2014-04-24

  The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.