1-(2'-((diethylamino)methyl)biphenyl-4-yl)ethanone | 1416779-25-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2'-((diethylamino)methyl)biphenyl-4-yl)ethanone
• 英文别名: 1-[4-[2-(Diethylaminomethyl)phenyl]phenyl]ethanone；1-[4-[2-(diethylaminomethyl)phenyl]phenyl]ethanone
• CAS: 1416779-25-3
• 化学式: C₁₉H₂₃NO
• 分子量: 281.398
• InChiKey: OAIZRTFYOKOASF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(N,N-二乙基氨基甲基)苯硼酸频哪醇酯 、 4-溴苯乙酮 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 0.17h， 以92%的产率得到1-(2'-((diethylamino)methyl)biphenyl-4-yl)ethanone
  参考文献：
  名称：

  Microwave-Mediated Suzuki–Miyaura Cross-Couplings of Thioether- and ortho-Substituted Methylphenylboronic Acid Esters

  摘要：

  Hiterto unsuccessful cross-couplings of ortho-substituted or thioether-substituted methylphenylboronates have now been achieved, under microwave conditions, enabling the synthesis of a library of novel biaryls. Tetrakis(triphenylphosphine) palladium and various bases, for example, sodium carbonate or cesium fluoride, were found to mediate the crucial C-C bond-forming cross-coupling reaction.

  DOI：

  10.1055/s-0032-1317205

文献信息

• Microwave-Mediated Suzuki–Miyaura Cross-Couplings of Thioether- and ortho-Substituted Methylphenylboronic Acid Esters
  作者：John Spencer、Christine Baltus、Neil Press

  DOI：10.1055/s-0032-1317205

  日期：——

  Hiterto unsuccessful cross-couplings of ortho-substituted or thioether-substituted methylphenylboronates have now been achieved, under microwave conditions, enabling the synthesis of a library of novel biaryls. Tetrakis(triphenylphosphine) palladium and various bases, for example, sodium carbonate or cesium fluoride, were found to mediate the crucial C-C bond-forming cross-coupling reaction.