(E)-3-[3-[[[2-(3-chloro-2-ethyl-N-[4-(trifluoromethyl)phenyl]sulfonylanilino)acetyl]amino]methyl]phenyl]prop-2-enoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-[3-[[[2-(3-chloro-2-ethyl-N-[4-(trifluoromethyl)phenyl]sulfonylanilino)acetyl]amino]methyl]phenyl]prop-2-enoic acid
• 化学式: C₂₇H₂₄ClF₃N₂O₅S
• 分子量: 581.0
• InChiKey: TWOSOMXCIVVMAC-NTEUORMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• EP2050446B1
  申请人：——

  公开号：EP2050446B1

  公开（公告）日：2014-05-07
• ANTI-CD70 ANTIBODY-DRUG CONJUGATES AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER AND IMMUNE DISORDERS
  申请人：LAW CHE-LEUNG

  公开号：US20110150908A1

  公开（公告）日：2011-06-23

  Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.