7-Hydroxy-4-methylheptanoic acid | 90201-57-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 7-Hydroxy-4-methylheptanoic acid
• CAS: 90201-57-3
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: AJHQDZNHDQULBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-Hydroxy-4-methylheptanoic acid 在 4-二甲氨基吡啶 、 C₂₄H₃₂FeN₆⁽²⁺⁾*2F₆Sb^(1-) 、 双氧水 、 三乙胺 作用下， 以 水 、 乙腈 为溶剂， 反应 0.35h， 生成 3-(2-Methyl-5-oxooxolan-2-yl)propyl acetate
  参考文献：
  名称：

  Directed Metal (Oxo) Aliphatic C–H Hydroxylations: Overriding Substrate Bias

  摘要：

  The first general strategy for a directing effect on metal (oxo)-promoted C-H hydroxylations is described. Carboxylic acid moieties on the substrate overcome unfavorable electronic, steric, and stereoelectronic biases in C-H hydroxylations catalyzed by the non-heme iron complex Fe(PDP). In a demonstration of the power of this directing effect, C-H oxidation is diverted away from an electronically favored C-1 H abstraction/rearrangement pathway in the paclitaxel framework to enable installation of C-2 oxidation in the naturally occurring oxidation state and stereoconfiguration.

  DOI：

  10.1021/ja301685r
• 作为产物：
  描述：

  2-methylpent-4-en-1-ol 在 草酰氯 、 palladium 10% on activated carbon 、 氢气 、 二甲基亚砜 、 9-硼双环[3.3.1]壬烷 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 3.64h， 生成 7-Hydroxy-4-methylheptanoic acid
  参考文献：
  名称：

  Directed Metal (Oxo) Aliphatic C–H Hydroxylations: Overriding Substrate Bias

  摘要：

  The first general strategy for a directing effect on metal (oxo)-promoted C-H hydroxylations is described. Carboxylic acid moieties on the substrate overcome unfavorable electronic, steric, and stereoelectronic biases in C-H hydroxylations catalyzed by the non-heme iron complex Fe(PDP). In a demonstration of the power of this directing effect, C-H oxidation is diverted away from an electronically favored C-1 H abstraction/rearrangement pathway in the paclitaxel framework to enable installation of C-2 oxidation in the naturally occurring oxidation state and stereoconfiguration.

  DOI：

  10.1021/ja301685r

文献信息

• PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS
  申请人：G.D. Searle & Co.

  公开号：EP0907666A1

  公开（公告）日：1999-04-14
• US5830936A
  申请人：——

  公开号：US5830936A

  公开（公告）日：1998-11-03
• [EN] PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS<br/>[FR] PARTICULES COMPRENANT DES COPOLYMERES AMPHIPHILES, POSSEDANT UN DOMAINE D'ENVELOPPE RETICULEE ET UN DOMAINE DE NOYAU UTILES ET AUTRES DANS DES APPLICATIONS PHARMACEUTIQUES
  申请人：——

  公开号：WO1997049387A1

  公开（公告）日：1997-12-31

  [EN] Provided are particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain. Also provided are compositions comprising such particles, including pharmaceutical compositions, methods of making the present particles, and methods of using such particles, for example for delivery of pharmaceutically active agents.
  [FR] L'invention concerne des particules comprenant des copolymères amphiphiles, possédant un domaine d'enveloppe réticulé et un domaine de noyau interne. Des compositions sont également décrites qui englobent de telles particules, y compris des compositions pharmaceutiques, des procédés de fabrication des présentes particules et des procédés d'utilisation de telles particules pour l'administation, par exemple, d'agents pharmacologiquement actifs.
• [EN] PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS<br/>[FR] PARTICULES COMPRENANT DES COPOLYMERES AMPHIPHILES, POSSEDANT UN DOMAINE DE RETICULATION CROISEE ET UN DOMAINE DE NOYAU INTERNE, UTILISABLES EN PHARMACOLOGIE ET AUTRES APPLICATIONS
  申请人：——

  公开号：WO1997049736A2

  公开（公告）日：1997-12-31

  [EN] Provided are methods of inhibiting bile acid uptake from the gastrointestinal system and reducing blood serum cholesterol by administering to a mammal, such as a human, an effective amount of particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain.
  [FR] La présente invention fournit des méthodes d'inhibition des remontées d'acide biliaire du système gastro-intestinal et permet de réduire le cholestérol de sérum du sang en administrant à un mammifère, tel qu'un humain, une quantité efficace de particules comprenant des copolymères amphiphiles, possédant un domaine de réticulation croisée et un domaine de noyau interne.