(2E)-N-methoxy-N-methyl-4-oxobut-2-enamide | 1420667-10-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2E)-N-methoxy-N-methyl-4-oxobut-2-enamide
• 英文别名: (E)-N-methoxy-N-methyl-4-oxobut-2-enamide
• CAS: 1420667-10-2
• 化学式: C₆H₉NO₃
• 分子量: 143.142
• InChiKey: KXUKEGBPMFPJCX-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (E)-4-hydroxy-N-methoxy-N-methylbut-2-enamide 在 manganese(IV) oxide 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以94%的产率得到(2E)-N-methoxy-N-methyl-4-oxobut-2-enamide
  参考文献：
  名称：

  Asymmetric synthesis of trifluoromethyl-piperidine based γ-amino acids and of trifluoromethyl-indolizidines

  摘要：

  The asymmetric synthesis of trifluoromethyl-piperidine-based gamma-aminoacids and of indolizidines bearing a trifluoromethyl group is reported. These rarely described compounds are prepared in a highly enantio-enriched form employing as key step an intramolecular Mannich type process, involving an enantiopure Tfm-aminoketal and ethyl oxobutenoate as aldehyde partner. Used strategy together with obtained compounds allows the access to a wide range of Tfm-N-(poly)heterocycles, structures of obvious interest for the research of new bioactive drugs. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2012.11.006

文献信息

• Asymmetric synthesis of trifluoromethyl-piperidine based γ-amino acids and of trifluoromethyl-indolizidines
  作者：Wahid Bux Jatoi、Agnès Desiront、Aurélie Job、Yves Troin、Jean-Louis Canet

  DOI：10.1016/j.jfluchem.2012.11.006

  日期：2013.1

  The asymmetric synthesis of trifluoromethyl-piperidine-based gamma-aminoacids and of indolizidines bearing a trifluoromethyl group is reported. These rarely described compounds are prepared in a highly enantio-enriched form employing as key step an intramolecular Mannich type process, involving an enantiopure Tfm-aminoketal and ethyl oxobutenoate as aldehyde partner. Used strategy together with obtained compounds allows the access to a wide range of Tfm-N-(poly)heterocycles, structures of obvious interest for the research of new bioactive drugs. (c) 2012 Elsevier B.V. All rights reserved.