N-[(E)-3-[2,4-diethoxy-3-[(3Z,5Z)-hepta-1,3,5-trien-2-yl]-1,2-dihydroquinolin-6-yl]-3-pyridin-4-ylbut-1-enyl]-N'-methylmethanimidamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(E)-3-[2,4-diethoxy-3-[(3Z,5Z)-hepta-1,3,5-trien-2-yl]-1,2-dihydroquinolin-6-yl]-3-pyridin-4-ylbut-1-enyl]-N'-methylmethanimidamide
• 化学式: C₃₁H₃₈N₄O₂
• 分子量: 498.7
• InChiKey: OTDDZIZUVCBUKK-PBSBHITOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T<br/>[FR] MODULATEURS DE ROR-GAMMA-T DE TYPE QUINOLINYLE À LIAISON PHÉNYLE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014062667A1

  公开（公告）日：2014-04-24

  The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.