(7S)-7-[5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl]-7-[[2-(1,2,4-triazol-4-yl)acetyl]amino]heptanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (7S)-7-[5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl]-7-[[2-(1,2,4-triazol-4-yl)acetyl]amino]heptanamide
• 化学式: C₂₄H₂₈N₈O₃
• 分子量: 476.5
• InChiKey: XZCCBUSIKIYLJE-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  154
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] COMPOUNDS FOR USE IN THE TREATMENT OF PARASITIC DISEASES<br/>[FR] COMPOSÉS DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES PARASITAIRES
  申请人：IRBM SCIENCE PARK S P A

  公开号：WO2014067985A1

  公开（公告）日：2014-05-08

  The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as Plasmodium falciparum, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.

  本发明涉及用于治疗寄生虫病的化合物，这些疾病是由寄生虫引起或传播的传染病。本发明的化合物对疟疾病原体特别活跃。这些化合物是寄生虫组蛋白去乙酰化酶（PfHDAC）的选择性抑制剂，能够抑制寄生虫（如疟原虫）的生长，且所需浓度低于抑制哺乳动物细胞生长所需的浓度。
• ANTICANCER AGENT
  申请人：Nagano Tetsuo

  公开号：US20130102776A1

  公开（公告）日：2013-04-25

  An anticancer agent comprising a compound represented by the formula (I) [R 1 represents hydrogen atom, hydroxyl group, a C 1-6 alkoxy group and the like; R 2 and R 3 represents hydrogen atom, a halogen atom, a C 1-6 alkyl group and the like; R 4 represents hydrogen atom, a C 1-6 alkyl group, a C 1-6 alkylsulfonyl group and the like; R 5 represents hydrogen atom or a substituent; represents a single bond or a double bond; R 6 and R 7 represents hydrogen atom, a C 1-6 alkyl group and the like; R 8 represents hydrogen atom, a C 1-6 alkyl group and the like; A represents —O—, —S—, or —CH 2 —; D represents —C═ or —N═; X represents methylene group, —O—, or —CO—; Q represents —N═ or —C(R 8 )═; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

  一种抗癌剂，包括由式(I)所表示的化合物[其中R1代表氢原子、羟基、C1-6烷氧基等；R2和R3代表氢原子、卤原子、C1-6烷基等；R4代表氢原子、C1-6烷基、C1-6烷基磺酰基等；R5代表氢原子或取代基；代表单键或双键；R6和R7代表氢原子、C1-6烷基等；R8代表氢原子、C1-6烷基等；A代表—O—、—S—或—CH2—；D代表—C═或—N═；X代表亚甲基、—O—或—CO—；Q代表—N═或—C(R8)═；Y代表杂环基或氨基]，该化合物对pim-1激酶表现出优异的抑制活性。