1-(2-prop-2-enyl-2H-quinolin-1-yl)but-3-en-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2-prop-2-enyl-2H-quinolin-1-yl)but-3-en-1-one
• 化学式: C₁₆H₁₇NO
• 分子量: 239.31
• InChiKey: BDZDJONJHPANKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] DIAGNOSTIC METHODS, THERAPEUTIC AGENTS AND USES THEREOF<br/>[FR] PROCÉDÉS DE DIAGNOSTIC, AGENT THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：METABOLON INC

  公开号：WO2018022866A1

  公开（公告）日：2018-02-01

  The present invention provides a compound of formula (I) or a salt thereof and their use as a biomarker in assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, diagnosing or monitoring chronic kidney disease. Compositions and method of making of the compound of formula (I) are also described.

  本发明提供了化合物(I)或其盐，并将其用作生物标志物来评估或监测受试者的肾功能，确定发展肾功能减退的易感性，根据肾功能水平对受试者进行分类，诊断或监测慢性肾病。还描述了化合物(I)的组成和制备方法。
• Methods of preparing cytotoxic benzodiazepine derivatives
  申请人：ImmunoGen, Inc.

  公开号：US10081640B2

  公开（公告）日：2018-09-25

  The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

  本发明涉及制备吲哚啉并二氮杂卓二聚化合物及其合成前体的新方法。
• Methods for the acylation of maytansinol
  申请人：IMMUNOGEN, INC.

  公开号：US10461449B2

  公开（公告）日：2019-10-29

  Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence of a drying agent. Also disclosed is an improved method of preparing an amino acid ester of maytansinol in which a nucleophile is added to the reaction mixture after completion of the reaction between maytansinol and an N-carboxyanhydride of an amino acid.

  本发明公开了一种通过在有干燥剂存在的情况下使 maytansinol 与一种氨基酸（NCA）的 N-羧酸酐反应来制备 maytansinol 氨基酸酯的方法。本发明还公开了一种制备麦丹素醇氨基酸酯的改进方法，在该方法中，在麦丹素醇与一种氨基酸的 N-羧基酸酐反应完成后，向反应混合物中加入亲核剂。
• Compounds, reagents, and uses thereof
  申请人：Metabolon, Inc.

  公开号：US10865183B2

  公开（公告）日：2020-12-15

  The present invention provides a compound of formula (I) or a salt thereof and their use as a biomarker in assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, diagnosing or monitoring chronic kidney disease. Compositions and method of making of the compound of formula (I) are also described.

  本发明提供了一种式（I）化合物或其盐及其作为生物标记物在评估或监测受试者肾功能、确定肾功能减退的易感性、根据肾功能水平对受试者进行分类、诊断或监测慢性肾病中的用途。还描述了式 (I) 化合物的组成和制造方法。
• [EN] METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES<br/>[FR] PROCÉDÉS DE PRÉPARATION DE DÉRIVÉS DE BENZODIAZÉPINE CYTOTOXIQUES
  申请人：IMMUNOGEN INC

  公开号：WO2018140435A9

  公开（公告）日：2018-12-27