(E,E)-2,6-bis(3-methoxy-4-dimethylaminostyryl)pyridine | 930284-53-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E,E)-2,6-bis(3-methoxy-4-dimethylaminostyryl)pyridine
• 英文别名: 4-[(E)-2-[6-[(E)-2-[4-(dimethylamino)-3-methoxyphenyl]ethenyl]pyridin-2-yl]ethenyl]-2-methoxy-N,N-dimethylaniline
• CAS: 930284-53-0
• 化学式: C₂₇H₃₁N₃O₂
• 分子量: 429.562
• InChiKey: WNKBRGRDSFRASQ-WFYKWJGLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (E,E)-2,6-bis(3-methoxy-4-dimethylaminostyryl)pyridine 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 生成 (E,E)-2,6-bis(3-hydroxy-4-dimethylaminostyryl)pyridine
  参考文献：
  名称：

  Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation

  摘要：

  New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by A beta fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for A beta fibril formation at IC50 of 0.1-2.7 mu M which is comparable to curcumin (IC50 of 0.8 mu M). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 mu M. In particular, 1-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.10.090
• 作为产物：
  描述：

  2,6-双(溴甲基)吡啶 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 (E,E)-2,6-bis(3-methoxy-4-dimethylaminostyryl)pyridine
  参考文献：
  名称：

  Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation

  摘要：

  New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by A beta fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for A beta fibril formation at IC50 of 0.1-2.7 mu M which is comparable to curcumin (IC50 of 0.8 mu M). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 mu M. In particular, 1-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.10.090

文献信息

• WO2008/30072
  申请人：——

  公开号：——

  公开（公告）日：——
• Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation
  作者：Seong Rim Byeon、Ji Hoon Lee、Ji-Hoon Sohn、Dong Chan Kim、Kye Jung Shin、Kyung Ho Yoo、Inhee Mook-Jung、Won Koo Lee、Dong Jin Kim

  DOI：10.1016/j.bmcl.2006.10.090

  日期：2007.3

  New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by A beta fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for A beta fibril formation at IC50 of 0.1-2.7 mu M which is comparable to curcumin (IC50 of 0.8 mu M). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 mu M. In particular, 1-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity. (c) 2006 Elsevier Ltd. All rights reserved.