methyl (2Z)-4-chloro-2-[(2-chloro-4-fluorophenyl)methylidene]-3-oxobutanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: methyl (2Z)-4-chloro-2-[(2-chloro-4-fluorophenyl)methylidene]-3-oxobutanoate
• 化学式: C₁₂H₉Cl₂FO₃
• 分子量: 291.1
• InChiKey: SRTUOKZRCLWVBM-WTKPLQERSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] ALTERNATIVE USES FOR HBV ASSEMBLY EFFECTORS<br/>[FR] NOUVELLES UTILISATIONS D'EFFECTEURS D'ASSEMBLAGE DU VHB
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2014074906A1

  公开（公告）日：2014-05-15

  Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV).

  本文描述了用于识别对乙型肝炎病毒（HBV）感染治疗有用的化合物的方法。
• Fluorescent-HAP: a diagnostic stain for HBV cores in cells
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

  公开号：US10006913B2

  公开（公告）日：2018-06-26

  Heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described. The present invention relates to heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery.

  本发明描述了基于杂芳基二氢嘧啶（HAP）的荧光染色剂（化合物），以及这种染色剂作为诊断试剂、病毒追踪剂和/或药物发现工具的用途。本发明涉及基于杂芳基二氢嘧啶（HAP）的荧光染色剂（化合物），以及此类染色剂作为诊断试剂、病毒追踪剂和/或药物发现工具的用途。
• MODULATORS OF VIRUS ASSEMBLY AS ANTIVIRAL AGENTS
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

  公开号：US20150218182A1

  公开（公告）日：2015-08-06

  In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle including regulation of intracellular trafficking and nucleic acid metabolism. Substituted pyrimidine modulators of the assembly of the HBV capsid structure and methods for their use are described.
• ALTERNATIVE USES FOR HBV ASSEMBLY EFFECTORS
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

  公开号：US20150292045A1

  公开（公告）日：2015-10-15

  Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV).
• FLUORESCENT-HAP: A DIAGNOSTIC STAIN FOR HBV CORES IN CELLS
  申请人：INDIAN UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATTION

  公开号：US20160274112A1

  公开（公告）日：2016-09-22

  Heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described. The present invention relates to heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery.