4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1,2-dihydroquinoline-6-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1,2-dihydroquinoline-6-carboxamide
• 化学式: C₂₂H₂₁N₅O
• 分子量: 371.4
• InChiKey: XIHXGUWPQGYPKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  85.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] METHODS AND KITS FOR THE PROGNOSIS OF COLORECTAL CANCER<br/>[FR] PROCÉDÉS ET KITS DE PRONOSTIC DU CANCER COLORECTAL
  申请人：INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS

  公开号：WO2014072517A1

  公开（公告）日：2014-05-15

  The invention relates to methods for predicting the risk of relapse of cancer patients as well as methods for providing personalized medicine to said patients based on the expression levels of different genes the expression of which is induced in response to TGF-beta stimulation. The invention also relates to kits for carrying out the diagnostic and predictive medicine methods.