2-phenyl-5-p-tolylsulfanyl-oxazole-4-carboxylic acid methyl ester | 54644-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-phenyl-5-p-tolylsulfanyl-oxazole-4-carboxylic acid methyl ester
• 英文别名: Methyl 5-(4-methylphenyl)sulfanyl-2-phenyl-1,3-oxazole-4-carboxylate
• CAS: 54644-07-4
• 化学式: C₁₈H₁₅NO₃S
• 分子量: 325.388
• InChiKey: BDVLRCXJXYEAQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  77.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-phenyl-5-p-tolylsulfanyl-oxazole-4-carboxylic acid methyl ester 在 氯化亚砜 、 水 、 sodium hydroxide 作用下， 以 乙醇 、 苯 为溶剂， 反应 1.0h， 生成 2-phenyl-5-(p-tolylthio)oxazole-4-carbonyl chloride
  参考文献：
  名称：

  2-aryl-5-arylsulfanyl-1,3-oxazole-4-carboxylic acids and their derivatives

  摘要：

  A convenient preparative procedure has been developed for the synthesis of previously unknown 2-aryl- 5-arylsulfanyl-1,3-oxazole-4-carboxylic acids and their functional derivatives from accessible multicenter substrates of the general formula Cl(2)C=C(NHCOR)C(O)OMe. The products turned out to be suitable for various subsequent transformations. Some oxazole-4-carboxylic acid hydrazide derivatives containing a substituted oxazol-5-yl fragment at the N(2) atom in the hydrazine moiety underwent recyclization on heating in acetic acid; as a result, one oxazole ring was converted into 1,3,4-oxadiazole.

  DOI：

  10.1134/s1070363210070212
• 作为产物：
  描述：

  5-methoxy-2-phenyl-oxazole-4-carbonyl chloride 在 三乙胺 作用下， 以 甲苯 、 苯 为溶剂， 生成 2-phenyl-5-p-tolylsulfanyl-oxazole-4-carboxylic acid methyl ester
  参考文献：
  名称：

  Scope and limitations of the Cornforth rearrangement

  摘要：

  DOI：

  10.1021/jo00898a040

文献信息

• Synthesis of 4-hetaryl-substituted 5-amino- and 5-sulfanyl-1,3-oxazole derivatives
  作者：V. M. Prokopenko、S. G. Pil’o、V. S. Brovarets

  DOI：10.1134/s1070363211020204

  日期：2011.2

  Previously unknown 5-amino- and 5-sulfanyl-1,3-oxazole derivatives containing a 1,3,4-oxadiazole, 1,3,4-thiadiazole, or 1,2,4-triazole fragment at C-4 were synthesized from accessible 1,3-oxazole-4-carboxylic acid hydrazides.
• 2-aryl-5-arylsulfanyl-1,3-oxazole-4-carboxylic acids and their derivatives
  作者：S. G. Pil’o、V. M. Prokopenko、V. S. Brovarets、B. S. Drach

  DOI：10.1134/s1070363210070212

  日期：2010.7

  A convenient preparative procedure has been developed for the synthesis of previously unknown 2-aryl- 5-arylsulfanyl-1,3-oxazole-4-carboxylic acids and their functional derivatives from accessible multicenter substrates of the general formula Cl(2)C=C(NHCOR)C(O)OMe. The products turned out to be suitable for various subsequent transformations. Some oxazole-4-carboxylic acid hydrazide derivatives containing a substituted oxazol-5-yl fragment at the N(2) atom in the hydrazine moiety underwent recyclization on heating in acetic acid; as a result, one oxazole ring was converted into 1,3,4-oxadiazole.
• Scope and limitations of the Cornforth rearrangement
  作者：Michael J. S. Dewar、Ignatius J. Turchi

  DOI：10.1021/jo00898a040

  日期：1975.5