(5Z)-3-[2-(4-methylphenyl)-2-oxoethyl]-5-[[4-(2-oxopropoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5Z)-3-[2-(4-methylphenyl)-2-oxoethyl]-5-[[4-(2-oxopropoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione
• 化学式: C₂₂H₁₉NO₅S
• 分子量: 409.5
• InChiKey: ICLRUKVOGVLPHM-JAIQZWGSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  106
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2
  申请人：Cardozo Timothy

  公开号：US20140142120A1

  公开（公告）日：2014-05-22

  The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity.
• US9261497B2
  申请人：——

  公开号：US9261497B2

  公开（公告）日：2016-02-16