3-[[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyl-1,3-dihydrotetrazol-5-yl)amino]methyl]-N,N-bis(cyclopropylmethyl)-8-propan-2-ylquinolin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyl-1,3-dihydrotetrazol-5-yl)amino]methyl]-N,N-bis(cyclopropylmethyl)-8-propan-2-ylquinolin-2-amine
• 化学式: C₃₂H₃₇F₆N₇
• 分子量: 633.7
• InChiKey: SSICEMDWJCDFSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  45
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  59
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• SELECTIVE BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP1981342B1

  公开（公告）日：2016-11-30
• [EN] PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES D'INHIBITEURS DE CETP
  申请人：REDDYS LAB LTD DR

  公开号：WO2014076568A2

  公开（公告）日：2014-05-22

  The present application discloses a pharmaceutical composition comprising a class of CETP inhibitors with improved oral bioavailability. The application further discloses compositions comprising a class of CETP inhibitor and at least one solubility improving material and optionally one or more wetting agents.