2-Hydroxybenzaldehyde;(4-methylquinolin-2-yl)hydrazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Hydroxybenzaldehyde;(4-methylquinolin-2-yl)hydrazine
• 英文别名: 2-hydroxybenzaldehyde;(4-methylquinolin-2-yl)hydrazine
• 化学式: C17H17N3O2
• 分子量: 295.34
• InChiKey: URIQJZQHWCERFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.03
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  88.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• QUINOLYL HYDRAZONES FOR THE TREATMENT OF TUBERCULOSIS AND RELATED DISEASES
  申请人：TECNIMEDE SOCIEDADE TECNICO-MEDICINAL S.A.

  公开号：US20150299128A1

  公开（公告）日：2015-10-22

  The invention provides quinolyl-hydrazones of Formula I, or pharmaceutically acceptable salts, esters, solvates, isomers and prodrugs thereof as well as pharmaceutical compositions containing these compounds for use in the prophylactic and/or therapeutic treatment of tuberculosis and related diseases, such as, diseases caused by nontuberculous mycobacteria and/or caused by Micobacterium leprae.

  本发明提供式I的喹诺酰肼化合物，或其药学上可接受的盐、酯、溶剂合物、异构体和前药，以及包含这些化合物的药物组合物，用于预防和/或治疗结核病和相关疾病，例如由非结核分枝杆菌引起的疾病和/或由麻风分枝杆菌引起的疾病。
• [EN] QUINOLYL HYDRAZONES FOR THE TREATMENT OF TUBERCULOSIS AND RELATED DISEASES<br/>[FR] QUINOLYL-HYDRAZONES POUR LE TRAITEMENT DE LA TUBERCULOSE ET DE MALADIES ASSOCIÉES
  申请人：TECNIMEDE SOCIEDADE TECNICO MEDICINAL S A

  公开号：WO2014081325A1

  公开（公告）日：2014-05-30

  The invention provides quinolyl-hydrazones of Formula I, or pharmaceutically acceptable salts, esters, solvates, isomers and prodrugs thereof as well as pharmaceutical compositions containing these compounds for use in the prophylactic and/or therapeutic treatment of tuberculosis and related diseases, such as, diseases caused by nontuberculous mycobacteria and/or caused by Micobacterium leprae.