(1S,2S)-5-ethyl-1-(6-methoxyquinolin-4-yl)-2-methyl-4-propylhept-6-en-1-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (1S,2S)-5-ethyl-1-(6-methoxyquinolin-4-yl)-2-methyl-4-propylhept-6-en-1-ol
• 化学式: C₂₃H₃₃NO₂
• 分子量: 355.5
• InChiKey: TZUXACFZQRFKDS-LYHSWCNTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES
  申请人：Mulholland Nicholas Phillip

  公开号：US20140206633A1

  公开（公告）日：2014-07-24

  The present invention relates to processes for the preparation of compounds of formula IB wherein A 1 , A 2 , A 3 , A 4 , L, Y 1 , Y 2 , R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the claims, comprising reacting a compound of formula (II) wherein Y 1 , Y 2 , L, A 1 , A 2 , R 1 , R 2 , R 3 , R 4 and R 5 are as defined for the compound of formula (I); with hydroxylamine in the presence of water, a base and a chiral phase transfer catalyst, which chiral phase transfer catalyst is a quinine derivative. The invention also relates to compounds of formula IB and enantiomerically enriched mixtures comprising compounds of formula IB.

  本发明涉及制备式IB化合物的过程，其中A1、A2、A3、A4、L、Y1、Y2、R1、R2、R3、R4和R5如所述的权利要求书中定义，包括在水、碱和手性相转移催化剂的存在下，将式II化合物与羟胺反应，其中Y1、Y2、L、A1、A2、R1、R2、R3、R4和R5如式I的化合物所定义；所述手性相转移催化剂为奎宁衍生物。本发明还涉及式IB化合物和包含式IB化合物的对映富集混合物。
• INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES
  申请人：Syngenta Crop Protection LLC

  公开号：US20140228577A1

  公开（公告）日：2014-08-14

  The present invention relates to compounds of formula (I): wherein A 1 , A 2 , A 3 , A 4 , G 1 , L, Y 1 , Y 2 , Y 3 , Y 4 , R 1 , R 2 , R 3 and R 4 are as defined in claim 1 ; or a salt or N-oxide thereof. Furthermore, the present invention relates to intermediates for preparing compounds of formula (I), to compositions comprising them and to methods of using them to combat and control insect, acarine, nematode and mollusc pests.

  本发明涉及式(I)的化合物：其中A1、A2、A3、A4、G1、L、Y1、Y2、Y3、Y4、R1、R2、R3和R4如权利要求1所定义；或其盐或N-氧化物。此外，本发明还涉及制备式(I)化合物的中间体，包含它们的组合物以及使用它们来对抗和控制昆虫、螨、线虫和软体动物害虫的方法。
• INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES
  申请人：Cassayre Jerome Yves

  公开号：US20140107161A1

  公开（公告）日：2014-04-17

  The present invention provides compounds of formula (I) wherein R 1 , R 2 , R 2 , R 3 , R 4 , G 1 , n, A 1 , A 2 , A 3 , A 4 , Y 1 , Y 2 , and Y 3 are as defined in the claims. The invention also relates to processes and intermediates for preparing these compounds, to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising these compounds and to methods of using these compounds to control insect, acarine, nematode and mollusc pests.
• PROCESS FOR THE PREPARATION OF ISOXAZOLINE COMPOUNDS
  申请人：MERIAL INC.

  公开号：US20170311601A1

  公开（公告）日：2017-11-02

  This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
• US8735362B2
  申请人：——

  公开号：US8735362B2

  公开（公告）日：2014-05-27