6-bromo-N-(1H-indol-2-ylmethyl)-2-(pyridin-2-yl)quinoline-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-bromo-N-(1H-indol-2-ylmethyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
• 英文别名: 6-bromo-N-(1H-indol-2-ylmethyl)-2-pyridin-2-ylquinoline-4-carboxamide
• 化学式: C₂₄H₁₇BrN₄O
• 分子量: 457.3
• InChiKey: GBJIMRMDKCTIDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Method for treating a chronic itch condition by administering small molecule MrgprX4 antagonists
  申请人：The Johns Hopkins University

  公开号：US11442059B2

  公开（公告）日：2022-09-13

  The present invention relates to cells and methods for detecting compounds that affect G protein coupled receptor mediated conditions. The invention also relates to methods for treating adverse drug reactions, autoimmune disorders, and pruritus.

  本发明涉及检测影响 G 蛋白偶联受体介导情况的化合物的细胞和方法。本发明还涉及治疗药物不良反应、自身免疫性疾病和瘙痒症的方法。
• COMPOSITIONS AND METHODS FOR TREATING G PROTEIN COUPLED RECEPTOR MEDIATED CONDITIONS
  申请人：The Johns Hopkins University

  公开号：US20200173985A1

  公开（公告）日：2020-06-04

  The present invention relates to cells and methods for detecting compounds that affect G protein coupled receptor mediated conditions. The invention also relates to methods for treating adverse drug reactions, autoimmune disorders, and pruritus.