5-甲基-2-呋喃磺酰胺 | 108583-53-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 中文名称: 5-甲基-2-呋喃磺酰胺
• 英文名称: 5-Methylfuran-2-sulfonamide
• 英文别名: 5-methyl-furan-2-sulfonic acid amide；5-Methyl-furan-2-sulfonsaeure-amid
• CAS: 108583-53-5
• 化学式: C₅H₇NO₃S
• 分子量: 161.181
• InChiKey: QFVRGWDWLKEIRP-UHFFFAOYSA-N

物化性质

• 沸点：
  314.7±44.0 °C(Predicted)
• 密度：
  1.372±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-[2-[2-(2-naphthyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl]propanoic acid 、 5-甲基-2-呋喃磺酰胺 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-(5-methylfuran-2-ylsulfonyl)-3-(2-(2-(naphthalen-2-yl)ethoxy)-4-(pyrazol-1-ylmethyl)phenyl)propanamide
  参考文献：
  名称：

  Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists

  摘要：

  A series of novel N-acylsulfonamide analogs were synthesized and evaluated for their binding affinity and antagonist activity for the EP3 receptor subtype. Representative compounds were also evaluated for their inhibitory effect on PGE(2)-induced uterine contraction in pregnant rats. Among those tested, a series of N-acylbenzenesulfonamide analogs were found to be more potent than the corresponding carboxylic acid analogs in both the in vitro and in vivo evaluations. The structure activity relationships (SAR) are also discussed. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.02.034
• 作为产物：
  描述：

  5-甲基呋喃-2-磺酰氯 在 ammonium hydroxide 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以73%的产率得到5-甲基-2-呋喃磺酰胺
  参考文献：
  名称：

  [EN] SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME
  [FR] SULFONYLURÉES, COMPOSÉS APPARENTÉS, ET LEUR UTILISATION

  摘要：

  公开号：

  WO2016131098A8

文献信息

• Sulfonamide derivatives
  申请人：Haap Wolfgang

  公开号：US20080085928A1

  公开（公告）日：2008-04-10

  Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein L, R 1 , R 2 , m and n have the meaning given in claim 1 and which can be used in the form of pharmaceutical compositions.

  公式（I）的化合物，以及 pharmaceutically acceptable salts and esters thereof，其中 L, R1, R2, m 和 n 的含义如权利要求 1 所述，并且可以以药物组合物的形式使用。
• A mild, efficient method for the synthesis of aromatic and aliphatic sulfonamides
  作者：Wing Yan Chan、Carl Berthelette

  DOI：10.1016/s0040-4039(02)00848-1

  日期：2002.6

  two-step method was developed for the synthesis of aromatic and aliphatic sulfonamides from the corresponding sulfinates using bis(2,2,2-trichloroethyl)azodicarboxylate as the electrophilic nitrogen source. The intermediate sulfonylhydrazides were obtained in very good yields and were cleaved under reductive conditions to deliver the desired sulfonamides. A variety of substituents in the aromatic ring

  开发了一种分两步的方法，使用双（2,2,2-三氯乙基）偶氮二羧酸酯作为亲电子氮源，由相应的亚磺酸酯合成芳族和脂族磺酰胺。中间体磺酰肼以非常高的产率获得，并且在还原条件下裂解以递送期望的磺酰胺。芳香环中的各种取代基以及杂环均具有良好的耐受性。
• The Reaction of Sulfinic Acid Salts with Hydroxylamine-<i>O</i>-sulfonic Acid. A Useful Synthesis of Primary Sulfonamides
  作者：S. L. Graham、T. H. Scholz

  DOI：10.1055/s-1986-31862

  日期：——

  Hydroxylamine-O-sulfonic acid is shown to be a useful reagent for converting alkane- and arenesulfinic acid salts to the corresponding sulfonamides.

  第 V 组金属化合物与三氧化硫的反应
• THE SULFONATION OF FURAN AND FURAN HOMOLOGS. PREPARATION OF FURANSULFONAMIDES¹
  作者：JOHN F. SCULLY、ELLIS V. BROWN

  DOI：10.1021/jo01371a003

  日期：1954.6