2-(6,8-Dihydropyrrolo[3,4-g]quinolin-7-yl)hexane-1-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(6,8-Dihydropyrrolo[3,4-g]quinolin-7-yl)hexane-1-sulfonamide
• 英文别名: 2-(6,8-dihydropyrrolo[3,4-g]quinolin-7-yl)hexane-1-sulfonamide
• 化学式: C₁₇H₂₃N₃O₂S
• 分子量: 333.5
• InChiKey: ONOIZYWVTMVITR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  84.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Novel benzimidazole derivatives as EP4 ligands
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160318905A1

  公开（公告）日：2016-11-03

  The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing pharmaceutical compositions for the treatment of disorders and indications associated with the EP4 receptor.

  本发明涉及一种新型苯并咪唑衍生物，其通式为(I)，以及其制备方法和用于制备治疗与EP4受体相关的疾病和适应症的药物组合物的用途。
• NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160214977A1

  公开（公告）日：2016-07-28

  The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected with the receptor EP4.

  本发明涉及通式(I)的新型苯并咪唑衍生物，其制备方法以及它们用于制备治疗与EP4受体相关的疾病和适应症的药物组合物的用途。
• Benzimidazole derivatives as EP4 ligands
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US10730856B2

  公开（公告）日：2020-08-04

  The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing pharmaceutical compositions for the treatment of disorders and indications associated with the EP4 receptor.

  本发明涉及通式（I）的新型苯并咪唑衍生物、其制备工艺及其用于制备治疗与 EP4 受体相关的疾病和适应症的药物组合物。
• NEUARTIGE BENZIMIDAZOLDERIVATE ALS EP4-ANTAGONISTEN
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2928884A1

  公开（公告）日：2015-10-14
• BENZIMIDAZOLDERIVATE ALS EP4-LIGANDEN
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP3083603B1

  公开（公告）日：2017-09-13