5-(3-methoxyphenyl)-3H-1,3-oxazole-2-thione | 681004-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(3-methoxyphenyl)-3H-1,3-oxazole-2-thione
• CAS: 681004-34-2
• 化学式: C₁₀H₉NO₂S
• 分子量: 207.253
• InChiKey: KOTXZVLZQCPXEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二硫化碳 、 2-azido-1-(3-methoxyphenyl)ethanone 在 三苯基膦 作用下， 以 1,4-二氧六环 为溶剂， 以73%的产率得到5-(3-methoxyphenyl)-3H-1,3-oxazole-2-thione
  参考文献：
  名称：

  A CONVENIENT SYNTHESIS OF 2-MERCAPTO-OXAZOLES VIA β-KETOAZIDE AND ITS APPLICATION TO A KEY INTERMEDIATE OF PI3Kγ INHIBITORS

  摘要：

  A convenient synthesis of 2-mercapto-oxazoles via the reaction of beta-ketoazide with triphenylphosphine (TPP) and carbon disulfide and its application to the synthesis of a key intermediate of phosphoinositide 3-kinase gamma (PI3K gamma) inhibitors are described.

  DOI：

  10.3987/com-13-12778

文献信息

• Chemical compounds
  申请人：Brown Lee Matthew

  公开号：US20050288515A1

  公开（公告）日：2005-12-29

  Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

  本文介绍了一种作为VEGFR2、CDK2和CDK4抑制剂有用的噁唑衍生物。所述发明还包括制备此类噁唑衍生物的方法以及在治疗增生性疾病中使用它们的方法。
• CHEMICAL COMPOUNDS
  申请人：Brown Lee Matthew

  公开号：US20070142437A1

  公开（公告）日：2007-06-21

  Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

  本文描述了一种有用的噁唑衍生物，可作为VEGFR2、CDK2和CDK4抑制剂。所述发明还包括制备这种噁唑衍生物的方法，以及在治疗高增殖性疾病方面使用它们的方法。
• EP1551813A4
  申请人：——

  公开号：EP1551813A4

  公开（公告）日：2007-07-11
• US7189712B2
  申请人：——

  公开号：US7189712B2

  公开（公告）日：2007-03-13
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004032882A2

  公开（公告）日：2004-04-22

  Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.