(E)-1-{2-hydroxy-4-methoxy-6-methoxymethoxy-3-[(1R,6R)-3-methyl-6-(1-methylethyl)-2-cyclohexen-1-yl]phenyl}-3-phenylprop-2-en-1-one | 1273019-46-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-1-{2-hydroxy-4-methoxy-6-methoxymethoxy-3-[(1R,6R)-3-methyl-6-(1-methylethyl)-2-cyclohexen-1-yl]phenyl}-3-phenylprop-2-en-1-one
• 英文别名: (E)-1-[2-hydroxy-4-methoxy-6-(methoxymethoxy)-3-[(1R,6R)-3-methyl-6-propan-2-ylcyclohex-2-en-1-yl]phenyl]-3-phenylprop-2-en-1-one
• CAS: 1273019-46-7
• 化学式: C₂₈H₃₄O₅
• 分子量: 450.575
• InChiKey: ILUPGTCMMZUIMJ-QWSZJCSHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (E)-1-{2-hydroxy-4-methoxy-6-methoxymethoxy-3-[(1R,6R)-3-methyl-6-(1-methylethyl)-2-cyclohexen-1-yl]phenyl}-3-phenylprop-2-en-1-one 在 三乙基硅烷 、 Wilkinson's catalyst 、 盐酸 、 甲醇 、 水 作用下， 以 苯 、 水 为溶剂， 反应 14.0h， 以67%的产率得到1-{2-hydroxy-4-methoxy-6-methoxymethoxy-3-[(1R,6R)-3-methyl-6-(1-methylethyl)-2-cyclohexen-1-yl]phenyl}-3-phenylpropan-1-one
  参考文献：
  名称：

  The First Total Syntheses of (+)-Hostmanin A and (+)-Methyllinderatin

  摘要：

  The first total syntheses of (+)-hostmanin A (1) and (+)-methyllinderatin (3) were achieved in four steps from a known compound, 1-{2,6-dihydroxy-4-methoxy-3-[(1R,6R)-3-methyl-6-(1-methylethyl)-2-cyclohexen-1-yl]phenyl}ethanone (6). The absolute configuration of (+)-methyllinderatin (3) was determined. Furthermore, (+)-hostmanin A (1), which was isolated as an inseparable mixture of hostmanin A and B, was synthesized as a sole component.

  DOI：

  10.3987/com-10-12084
• 作为产物：
  描述：

  1-{2,6-dihydroxy-4-methoxy-3-[(1R,6R)-3-methyl-6-(1-methylethyl)-2-cyclohexen-1-yl]phenyl}ethanone 在 potassium tert-butylate 、 potassium carbonate 作用下， 以 丙酮 、 叔丁醇 为溶剂， 反应 4.0h， 生成 (E)-1-{2-hydroxy-4-methoxy-6-methoxymethoxy-3-[(1R,6R)-3-methyl-6-(1-methylethyl)-2-cyclohexen-1-yl]phenyl}-3-phenylprop-2-en-1-one
  参考文献：
  名称：

  The First Total Syntheses of (+)-Hostmanin A and (+)-Methyllinderatin

  摘要：

  The first total syntheses of (+)-hostmanin A (1) and (+)-methyllinderatin (3) were achieved in four steps from a known compound, 1-{2,6-dihydroxy-4-methoxy-3-[(1R,6R)-3-methyl-6-(1-methylethyl)-2-cyclohexen-1-yl]phenyl}ethanone (6). The absolute configuration of (+)-methyllinderatin (3) was determined. Furthermore, (+)-hostmanin A (1), which was isolated as an inseparable mixture of hostmanin A and B, was synthesized as a sole component.

  DOI：

  10.3987/com-10-12084

文献信息

• The First Total Syntheses of (+)-Hostmanin A and (+)-Methyllinderatin
  作者：Masayuki Yamashita、Junko Kitao、Naoko Kitamura、Nozomi Kumo、Ai Kurume、Kenji Arimitsu、Hiroki Iwasaki、Minoru Ozeki

  DOI：10.3987/com-10-12084

  日期：——

  The first total syntheses of (+)-hostmanin A (1) and (+)-methyllinderatin (3) were achieved in four steps from a known compound, 1-2,6-dihydroxy-4-methoxy-3-[(1R,6R)-3-methyl-6-(1-methylethyl)-2-cyclohexen-1-yl]phenyl}ethanone (6). The absolute configuration of (+)-methyllinderatin (3) was determined. Furthermore, (+)-hostmanin A (1), which was isolated as an inseparable mixture of hostmanin A and B, was synthesized as a sole component.