5-甲基-己烷-2,4-二醇 | 54877-00-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5-甲基-己烷-2,4-二醇
• 英文名称: 5-methyl-hexane-2,4-diol
• 英文别名: 5-Methyl-hexan-2,4-diol；5-Methyl-2,4-hexandiol；5-Methylhexane-2,4-diol
• CAS: 54877-00-8
• 化学式: C₇H₁₆O₂
• mdl: MFCD06407586
• 分子量: 132.203
• InChiKey: YRDZJWZHGKDMBL-UHFFFAOYSA-N

物化性质

• 熔点：
  44.24°C (estimate)
• 沸点：
  233.16°C (rough estimate)
• 密度：
  0.9744 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-甲基-己烷-2,4-二醇 在 三乙胺 、 三氯化磷 作用下， 生成 2-Chloro-4-isopropyl-6-methyl-[1,3,2]dioxaphosphinane
  参考文献：
  名称：

  Nagar, P. N., Phosphorus and Sulfur and the Related Elements, 1988, vol. 40, p. 177 - 182

  摘要：

  DOI：
• 作为产物：
  描述：

  异丁酰基丙酮 在 乙醚 、 镍 作用下， 125.0 ℃ 、19.61 MPa 条件下， 生成 5-甲基-己烷-2,4-二醇
  参考文献：
  名称：

  Hydrogenation and Hydrogenolysis of 1,3-Diketones

  摘要：

  DOI：

  10.1021/ja01327a041

文献信息

• Comparative Safety of Filgrastim versus Sargramostim in Patients Receiving Myelosuppressive Chemotherapy
  作者：Gary Milkovich、Ronald J. Moleski、John F. Reitan、David M. Dunning、Gene A. Gibson、Thomas A. Paivanas、Susan Wyant、R. Jake Jacobs

  DOI：10.1592/phco.20.19.1432.34861

  日期：2000.12

  Study Objective. To compare rates of adverse events with filgrastim versus sargramostim when given prophylactically to patients receiving myelosuppressive chemotherapy. Design. Retrospective review with center crossover. Setting. Ten United States outpatient chemotherapy centers. Patients. Four hundred ninety patients treated for lung, breast, lymphatic system, or ovarian tumors. Intervention. Prophylactic use of filgrastim or sargramostim, with dosages at investigator discretion. Measurements and Main Results. The frequency and severity of adverse events and the frequency of switching to the alternative CSF were assessed. There was no difference in infectious fever. Fever unexplained by infection was more common with sargramostim (7% vs 1%, p<0.001), as were fatigue, diarrhea, injection site reactions, other dermatologic disorders, and edema (all p<0.05). Skeletal pain was more frequent with filgrastim (p=0.06). Patients treated with sargramostim switched to the alternative agent more often (p<0.001). Conclusion. Adverse events were less frequent with filgrastim than with sargramostim, suggesting that quality of life and treatment costs also may differ.

  研究目的：比较在接受骨髓抑制化疗的患者中，预防性使用菲尔格司亭与沙格莫司亭的副作用发生率。 设计：回顾性研究，具有中心交叉设计。 设置：美国十个门诊化疗中心。 患者：490名接受肺癌、乳腺癌、淋巴系统或卵巢肿瘤治疗的患者。 干预：在研究者的判断下，预防性使用菲尔格司亭或沙格莫司亭，剂量由研究者自行决定。 测量与主要结果：评估了副作用的发生频率和严重程度，以及转用替代性粒细胞生长因子的频率。感染引起的发热没有差异。与沙格莫司亭相比，不明原因的发热更为常见（7%对1%，p<0.001），疲劳、腹泻、注射部位反应、其他皮肤病和水肿也更常见（均p<0.05）。骨骼疼痛在使用菲尔格司亭的患者中更为频繁（p=0.06）。接受沙格莫司亭治疗的患者更常转用替代药物（p<0.001）。 结论：与沙格莫司亭相比，使用菲尔格司亭的副作用发生率更低，这表明生活质量和治疗费用也可能存在差异。
• Arene-catalysed lithiation reactions with lithium at low temperature
  作者：Miguel Yus、Diego J. Ramón

  DOI：10.1039/c39910000398

  日期：——

  The reaction of functionalized alkyl chlorides or phenyl sulphides with an excess of lithium powder in the presence of a catalytic amount of an arene (1%; naphthalene, biphenyl, 4,4′-di-tert-butylbiphenyl) in tetrahydrofuran (THF) at –78 °C gives the corresponding organolithium compounds, which react with electrophiles such as water, iso-butyraldehyde, or cyclohexanone to yield the expected reaction products.

  官能化的烷基氯化物或苯基硫化物与过量的锂粉在催化量的炔类（1%；萘、联苯、4,4′-二叔丁基联苯）存在下于-78 °C的四氢呋喃（THF）中反应，得到相应的有机锂化合物，这些化合物与水、异丁醛或环己酮等亲电物反应，得到预期的反应产物。
• METHOD FOR PRODUCING DIVINYL ETHER COMPOUND HAVING ALKYLENE SKELETON
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20220033334A1

  公开（公告）日：2022-02-03

  A method of purifying a divinyl ether compound having an alkylene skeleton may take place with low energy and in a simplified manner. Such a method for producing a divinyl ether compound may include: reacting a compound of formula (1) wherein R 1 is an alkylene group having 4 to 20 carbon atoms, with acetylene by using an alkali metal catalyst; and purifying the divinyl ether compound of formula (2) which is obtained in the reacting, without an extraction.

  一种用低能耗和简化方式进行的纯化含有烯基醚基团的烯基醚化合物的方法。生产烯基醚化合物的方法可能包括：通过使用碱金属催化剂将具有4到20个碳原子的烯基醚基团的化合物（式1）与乙炔发生反应；并在反应中获得的烯基醚化合物（式2）进行纯化，而无需提取。
• The reaction of trialkylvinylborates with aldehydes as applied to syntheses of 1,3-alkanediols, 1-chloro-3-heptanol and a cyclopropane derivative
  作者：K. Utimoto、K. Uchida、H. Nozaki

  DOI：10.1016/0040-4020(77)80382-7

  日期：1977.1

  R2BCHR-CH2-CH(OLi)R' (2) or its borate form (3). Oxidation of the adducts with alkaline hydrogen peroxide gives ca. 1:1 mixture of diastereomeric 1,3-alkanediols in good yields. On the other hand, the reaction of BrMg[R3BCHCH2] with R'CHO affords less satisfactory results. Successive treatment of 2 (R = n-Bu, R' = H) with PCl5 and alkaline H2O2 gives HOCHBu-CH2-CH2Cl (6). Treatment of Et2BCHEt-CH2-CHCl-Ph

  用Li [R 3 BCH ＝ CH 2 ]处理R'CHO得到加合物，其被认为是R 2 BCHR-CH 2 -CH（OLi）R'（2）或其硼酸盐形式（3）。用碱性过氧化氢对加合物进行氧化可得到大约。非对映异构体1,3-链烷二醇的1：1混合物，收率高。另一方面，BrMg [R 3 BCH ＝ CH 2 ]与R'CHO的反应不能令人满意。用PCl 5和碱性H 2 O 2连续处理2（R = n-Bu，R'= H），得到HOCHBu-CH 2 -CH 2 Cl（6）。用NaOH水溶液处理Et 2 BCHEt-CH 2 -CHCl-Ph产生1-乙基-2-苯基环丙烷7。
• Concentrated, stable, translucent or clear, fabric softening compositions including chelants
  申请人：Wahl Hoffman Errol

  公开号：US20050202998A1

  公开（公告）日：2005-09-15

  Clear or translucent fabric softening compositions having a biodegradable fabric softening active and an added chelating agent are disclosed. The biodegradable fabric softening active preferably has the formula: wherein each R substituent is hydrogen or a short chain C 1 -C 6 , preferably C 1 -C 3 alkyl or hydroxyalkyl group, e.g., methyl (most preferred), ethyl, propyl, hydroxyethyl, and the like, benzyl, or mixtures thereof; each m is 2 or 3; each n is from 1 to about 4, preferably 2; each Y is —O—(O)C—, —(R)N—(O)C—, —C(O)—N(R)—, or —C(O)—O—, preferably —O—(O)C—; the sum of carbons in each R 1 , plus one when Y is —O—(O)C— or —(R)N—(O)—, is C 6 -C 22 , preferably C 12-22 , more preferably C 14 -C 20 , but no more than one R 1 or YR 1 sum being less than about 12 and then the other R 1 or YR 1 sum is at least about 16, with each R 1 being a long chain C 5 -C 21 (or C 6 -C 22 ), preferably C 9 -C 19 (or C 9 -C 20 ), most preferably C 11 -C 17 (or C 12 -C 18 ), straight, branched, unsaturated or polyunsatruated alkyl, the average Iodine Value of the parent fatty acid of the R 1 being from about 20 to about 140. The chelating agent is preferably diaminetriaminepentaacetic acid. The compositions display excellant clarity with a percentage haze in the transmission mode of a Hunter Color analysis of less than 90%, preferably less than 50%.

  本文揭示了具有可生物降解织物柔软活性剂和添加螯合剂的透明或半透明织物柔软组合物。可生物降解织物柔软活性剂优选具有以下公式： 其中，每个R取代基是氢或短链C1-C6，优选是C1-C3烷基或羟基烷基，例如，甲基（最优选），乙基，丙基，羟乙基等，苯甲基或其混合物；每个m为2或3；每个n为1至约4，优选为2；每个Y为—O—（O）C—，—（R）N—（O）C—，—C（O）—N（R）—或—C（O）—O—，优选为—O—（O）C—；当Y为—O—（O）C—或—（R）N—（O）—时，每个R1中碳的总数加一为C6-C22，优选为C12-22，更优选为C14-C20，但不超过一个R1或YR1总和小于约12，然后另一个R1或YR1总和至少约为16，每个R1为长链C5-C21（或C6-C22），优选为C9-C19（或C9-C20），最优选为C11-C17（或C12-C18），直链、支链、不饱和或多不饱和烷基，R1的父脂肪酸的平均碘值约为20至约140。螯合剂优选为二氨基三乙酸五钠盐。该组合物在Hunter Color分析的透射模式下具有出色的清晰度，其百分之雾度小于90％，优选小于50％。