1-Amino-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]-8-nitrosoquinolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Amino-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]-8-nitrosoquinolin-2-one
• 英文别名: 1-amino-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]-8-nitrosoquinolin-2-one
• 化学式: C₂₁H₂₄N₄O₄
• 分子量: 396.4
• InChiKey: KGYZXWHZZNKZBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE
  申请人：The USA, as represented by the Secretary, Department of Health and Human Services

  公开号：US20140187645A1

  公开（公告）日：2014-07-03

  This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.

  本公开涉及发现(R,R)-和(R,S)-芬特罗类似物，其在结合β2-肾上腺素能受体方面具有高效性。提供了这些类似物的示例化学结构。还提供了包括所述(R,R)-芬特罗和芬特罗类似物的制药组合物，以及使用这些化合物和组合物治疗心脏疾病（如充血性心力衰竭）和肺部疾病（如哮喘或慢性阻塞性肺疾病）的方法。