(+/-)-phenyl α-(2-formyl-3-hydroxyphenyl)ethyl sulfide | 134455-68-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (+/-)-phenyl α-(2-formyl-3-hydroxyphenyl)ethyl sulfide
• 英文别名: 2-hydroxy-6-(1-phenylsulfanylethyl)benzaldehyde
• CAS: 134455-68-8
• 化学式: C₁₅H₁₄O₂S
• 分子量: 258.341
• InChiKey: XMFZWHDVHUAXPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.06
• 重原子数：
  18.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (+/-)-phenyl α-(2-formyl-3-hydroxyphenyl)ethyl sulfide 、 水 生成 2-hydroxy-3-methyl-2-phenyl-1,3-dihydro-2-benzothiophene-1,7-diol
  参考文献：
  名称：

  CARROLL, JAMES D.;JONES, PAUL R.;BALL, RICHARD G., J. ORG. CHEM., 56,(1991) N3, C. 4208-4213

  摘要：

  DOI：
• 作为产物：
  描述：

  (+/-)-N,N-dimethyl-α-(2-formyl-3-methoxyphenyl)ethylamine 在 盐酸 、 sodium hydroxide 、 氢溴酸 作用下， 以 水 为溶剂， 反应 16.5h， 生成 (+/-)-phenyl α-(2-formyl-3-hydroxyphenyl)ethyl sulfide
  参考文献：
  名称：

  Novel ring-chain tautomers derived from (o-formylphenyl)ethylamines

  摘要：

  The synthesis and characterization of some (o-formylphenyl)ethylamines are described. Formylation with DMF of regioselectively lithiated N,N-dimethyl-alpha-(m-methoxyphenyl)ethylamine (1) has provided a route to an unusual ring-chain tautomeric system in which the ring has the dihydroisoindolium structure. The ring tautomers, with two chiral centers, consist of unequal amounts of two racemates, which undergo rapid, base-catalyzed interconversion at ambient temperature on the 360-MHz NMR time scale. The geometry and relative energies of the diastereomeric ring structures were estimated from MMP2 calculations. The trans dihydroisoindolium 3,5-dinitrobenzoate (4d) was characterized by X-ray diffraction, and its geometry was compared with that predicted by calculation. From NMR experiments with the simpler amino aldehyde 6, it has been concluded that, although a methoxy or hydroxy substituent ortho to the formyl group is not a structural requirement for ring tautomerism, it serves to favor the ring over the chain tautomer. The (o-formylphenyl)ethyl sulfides 8 and 9, obtained by nucleophilic displacement of the methiodides, show no propensity for ring formation.

  DOI：

  10.1021/jo00013a025

文献信息

• CARROLL, JAMES D.;JONES, PAUL R.;BALL, RICHARD G., J. ORG. CHEM., 56,(1991) N3, C. 4208-4213
  作者：CARROLL, JAMES D.、JONES, PAUL R.、BALL, RICHARD G.

  DOI：——

  日期：——
• Novel ring-chain tautomers derived from (o-formylphenyl)ethylamines
  作者：James D. Carroll、Paul R. Jones、Richard G. Ball

  DOI：10.1021/jo00013a025

  日期：1991.6

  The synthesis and characterization of some (o-formylphenyl)ethylamines are described. Formylation with DMF of regioselectively lithiated N,N-dimethyl-alpha-(m-methoxyphenyl)ethylamine (1) has provided a route to an unusual ring-chain tautomeric system in which the ring has the dihydroisoindolium structure. The ring tautomers, with two chiral centers, consist of unequal amounts of two racemates, which undergo rapid, base-catalyzed interconversion at ambient temperature on the 360-MHz NMR time scale. The geometry and relative energies of the diastereomeric ring structures were estimated from MMP2 calculations. The trans dihydroisoindolium 3,5-dinitrobenzoate (4d) was characterized by X-ray diffraction, and its geometry was compared with that predicted by calculation. From NMR experiments with the simpler amino aldehyde 6, it has been concluded that, although a methoxy or hydroxy substituent ortho to the formyl group is not a structural requirement for ring tautomerism, it serves to favor the ring over the chain tautomer. The (o-formylphenyl)ethyl sulfides 8 and 9, obtained by nucleophilic displacement of the methiodides, show no propensity for ring formation.