2,2,3,6,7-Pentamethylpyrrolo[3,2-h]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,2,3,6,7-Pentamethylpyrrolo[3,2-h]quinoline
• 英文别名: 2,2,3,6,7-pentamethylpyrrolo[3,2-h]quinoline
• 化学式: C₁₆H₁₈N₂
• 分子量: 238.33
• InChiKey: FJTSOQCTSAFGTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SHIP1 MODULATORS AND METHODS RELATED THERETO<br/>[FR] MODULATEURS DE SHIP1 ET PROCÉDÉS ASSOCIÉS
  申请人：AQUINOX PHARMACEUTICALS INC

  公开号：WO2014110036A1

  公开（公告）日：2014-07-17

  Compounds of formula (I): [Formula should be inserted here]; where [Formula should be inserted here], n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.