benzyl N-[2-[[4-[(3S,4S,5R)-4-amino-3-methyl-5-[(2-methylpropan-2-yl)oxycarbonylamino]piperidin-1-yl]pyridin-3-yl]carbamoyl]-7-morpholin-4-ylquinolin-3-yl]carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: benzyl N-[2-[[4-[(3S,4S,5R)-4-amino-3-methyl-5-[(2-methylpropan-2-yl)oxycarbonylamino]piperidin-1-yl]pyridin-3-yl]carbamoyl]-7-morpholin-4-ylquinolin-3-yl]carbamate
• 化学式: C₃₈H₄₆N₈O₆
• 分子量: 710.8
• InChiKey: SXTNCRRYVNPYAA-RDAGYPQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  52
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  173
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• [EN] BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS<br/>[FR] COMPOSÉS DE CARBOXAMIDE AROMATIQUE BICYCLIQUE UTILES COMME INHIBITEURS DE PIM KINASE
  申请人：INCYTE CORP

  公开号：WO2014110574A1

  公开（公告）日：2014-07-17

  The present disclosure describes bicyclic aromatic carboxamide derivatives of formula (I), as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.