5,7-dichloro-4-(phenylcarbamoylamino)-3,4-dihydro-2H-quinoline-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,7-dichloro-4-(phenylcarbamoylamino)-3,4-dihydro-2H-quinoline-1-carboxylic acid
• 化学式: C₁₇H₁₅Cl₂N₃O₃
• 分子量: 380.2
• InChiKey: ROQUXQODMVKNPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  81.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• COMPOSITIONS FOR THE TREATMENT OF PERVASIVE DEVELOPMENT DISORDERS
  申请人：Case Western Reserve University

  公开号：EP3485882A1

  公开（公告）日：2019-05-22

  A method of treating a pervasive development disorder in a subject includes administering to the subject an amount of an NMDAR antagonist effective to ameliorate biochemical and functional abnormalities in the subject associated with loss-of-function mutations of the gene encoding methyl-CpG binding protein 2 (MeCP2).

  一种治疗受试者广泛性发育障碍的方法，包括向受试者施用一定量的NMDAR拮抗剂，以有效改善受试者与编码甲基-CPG结合蛋白2（MeCP2）基因的功能缺失突变相关的生化和功能异常。
• NMDAR antagonist for the treatment of pervasive development disorders
  申请人：Case Western Reserve University

  公开号：US10555916B2

  公开（公告）日：2020-02-11

  A method of treating a pervasive development disorder in a subject includes administering to the subject an amount of an NMDAR antagonist effective to ameliorate biochemical and functional abnormalities in the subject associated with loss-of-function mutations of the gene encoding methyl-CpG binding protein 2 (MeCP2).

  一种治疗受试者广泛性发育障碍的方法，包括向受试者施用一定量的NMDAR拮抗剂，以有效改善受试者与编码甲基-CPG结合蛋白2（MeCP2）基因的功能缺失突变相关的生化和功能异常。
• Compositions and methods for the treatment of pervasive development disorders
  申请人：Case Western Reserve University

  公开号：US11213494B2

  公开（公告）日：2022-01-04

  A method of treating a pervasive development disorder in a subject includes administering to the subject a therapeutically effective amount of an NMDAR antagonist, with an intermittent dosing regimen.

  一种治疗受试者广泛性发育障碍的方法包括向受试者施用治疗有效量的 NMDAR 拮抗剂，并采用间歇性给药方案。
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF PERVASIVE DEVELOPMENT DISORDERS
  申请人：Case Western Reserve University

  公开号：EP2948135B1

  公开（公告）日：2019-01-02
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF PERVASIVE DEVELOPMENT DISORDERS<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE TROUBLES ENVAHISSANTS DU DÉVELOPPEMENT
  申请人：UNIV CASE WESTERN RESERVE

  公开号：WO2014117089A1

  公开（公告）日：2014-07-31

  A method of treating a pervasive development disorder in a subject includes administering to the subject an amount of an NMDAR antagonist effective to ameliorate biochemical and functional abnormalities in the subject associated with loss-of-function mutations of the gene encoding methyl-CpG binding protein 2 (MeCP2).