(6R,8S)-8-[2-(2-hydroxypropan-2-yl)phenyl]-6-[3-[(E)-2-(7-methylquinolin-2-yl)ethenyl]phenyl]-9-oxa-5-thiaspiro[2.8]undecan-10-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (6R,8S)-8-[2-(2-hydroxypropan-2-yl)phenyl]-6-[3-[(E)-2-(7-methylquinolin-2-yl)ethenyl]phenyl]-9-oxa-5-thiaspiro[2.8]undecan-10-one
• 化学式: C₃₆H₃₇NO₃S
• 分子量: 563.7
• InChiKey: LSJMNUJVFCIXKS-JSVIKWKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  41
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  84.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• TAPE PREPARATION OF WT1 PEPTIDE CANCER VACCINE FOR TRANSDERMAL ADMINISTRATION
  申请人：Osaka University

  公开号：US20140220105A1

  公开（公告）日：2014-08-07

  The present invention provides a cancer vaccine tape preparation for inducing cellular immunity, comprising: a support, an adhesive layer comprising an adhesive disposed on one side of the support, wherein the adhesive layer carries a combination of: (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a first cellular immunity induction promoter. The tape preparation can provides high efficacy.