(3aR,5R,6R,6aR)-5-[(2R)-1-hydroxypropan-2-yl]-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aR,5R,6R,6aR)-5-[(2R)-1-hydroxypropan-2-yl]-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol
• 化学式: C₁₀H₁₈O₅
• 分子量: 218.25
• InChiKey: RMCNBSJLZFVCEJ-JGKVKWKGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHOD FOR MAKING A PRECURSOR OF L-FUCOSE FROM D-GLUCOSE
  申请人：Glycom A/S

  公开号：US20140235848A1

  公开（公告）日：2014-08-21

  A method that can be used to make a precursor of L-fucose from D-glucose that includes the steps of a) making a compound of formula (1) from D-glucose, formula (1) wherein R 1 is acyloxy, and Q is a group (a), (b), (c) or (d), formula (a), (b), (c) or (d) or wherein R 1 is OH, and Q is a group (e), (f) or (g); formula (e), (f) or (g) wherein R 2 is acyloxy and R 3 is a sulphonyl leaving group; and b) producing 6-deoxy-L-talose from the compound of formula (1) formed in step a), wherein the moiety is a highly lipophilic protecting group; compounds according to formula (1), and use of a compound according to formula (1) are provided.
• NEW SYNTHESIS OF FUCOSE
  申请人：GLYCOM A/S

  公开号：US20140235840A1

  公开（公告）日：2014-08-21

  A process for converting D-glucose into L-fucose, where a first aspect of the disclosure relates to a method of making a compound of formula (1) wherein R is independently H, alkyl or phenyl or, preferably, wherein the two germinal R groups together with the carbon atom to which they are attached form a C3-s cycloalkylidene group, including the step of treating a compound of formula (2) wherein R is defined above and R 1 is a sulphonate leaving group, with a reducing complex metal hydride and, preferably, a base to form the compound of formula (1); a compound of formula (13).