5-fluoro-3-(1,3-diphenylprop-2-ynyl)-1H-indole | 1380496-75-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 5-fluoro-3-(1,3-diphenylprop-2-ynyl)-1H-indole
• 英文别名: 3-(1,3-diphenylprop-2-ynyl)-5-fluoro-1H-indole
• CAS: 1380496-75-2
• 化学式: C₂₃H₁₆FN
• 分子量: 325.385
• InChiKey: ZYMQUPAJLPGJSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-氟吲哚 、 1,3-二苯基-2-丙炔-1-醇 在 bismuth (III) nitrate pentahydrate 作用下， 反应 4.0h， 以94%的产率得到5-fluoro-3-(1,3-diphenylprop-2-ynyl)-1H-indole
  参考文献：
  名称：

  Condensation of propargylic alcohols with indoles and carbazole in [bmim][PF6]/Bi(NO3)3·5H2O: a simple high yielding propargylation method with recycling and reuse of the ionic liquid

  摘要：

  Propargylation of a variety of substituted indoles as well as mono- and di-propargylation of carbazole are achieved in 80-94% isolated yields by employing catalytic amounts (10 mol%) of the readily available Bi(NO3)(3)center dot 5H(2)O in [bmim][PF6] ionic liquid (IL), with repeated recycling and reuse of the IL. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.026

文献信息

• Condensation of propargylic alcohols with indoles and carbazole in [bmim][PF6]/Bi(NO3)3·5H2O: a simple high yielding propargylation method with recycling and reuse of the ionic liquid
  作者：G.G.K.S. Narayana Kumar、Gopalakrishnan Aridoss、Kenneth K. Laali

  DOI：10.1016/j.tetlet.2012.04.026

  日期：2012.6

  Propargylation of a variety of substituted indoles as well as mono- and di-propargylation of carbazole are achieved in 80-94% isolated yields by employing catalytic amounts (10 mol%) of the readily available Bi(NO3)(3)center dot 5H(2)O in [bmim][PF6] ionic liquid (IL), with repeated recycling and reuse of the IL. (C) 2012 Elsevier Ltd. All rights reserved.