2-(2,2-di-indol-3-yl-ethyl)-N,N-dimethyl-aniline | 120499-36-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(2,2-di-indol-3-yl-ethyl)-N,N-dimethyl-aniline
• 英文别名: 2-(2,2-Di-indol-3-yl-aethyl)-N,N-dimethyl-anilin；2-(2,2-Di(1H-indol-3-yl)ethyl)-N,N-dimethylaniline；2-[2,2-bis(1H-indol-3-yl)ethyl]-N,N-dimethylaniline
• CAS: 120499-36-7
• 化学式: C₂₆H₂₅N₃
• 分子量: 379.505
• InChiKey: OFALCFCSOABDDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  34.8
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2,2-di-indol-3-yl-ethyl)-N,N-dimethyl-aniline 在 水 、 溶剂黄146 、 sodium nitrite 作用下， 生成 2-[2,2-bis-(1-nitroso-indol-3-yl)-ethyl]-N,N-dimethyl-aniline
  参考文献：
  名称：

  Schmitz-Dumont; ter Horst, Justus Liebigs Annalen der Chemie, vol. 538, p. 270

  摘要：

  DOI：
• 作为产物：
  描述：

  2-[2,2-双-(1H-吲哚-3-基)-乙基]-苯胺 、 碘甲烷 在 potassium carbonate 、 丙酮 作用下， 生成 2-(2,2-di-indol-3-yl-ethyl)-N,N-dimethyl-aniline
  参考文献：
  名称：

  Schmitz -Dumont; ter Horst, Justus Liebigs Annalen der Chemie, vol. 538, p. 270

  摘要：

  DOI：

文献信息

• Schmitz-Dumont; ter Horst, Justus Liebigs Annalen der Chemie, vol. 538, p. 273
  作者：Schmitz-Dumont、ter Horst

  DOI：——

  日期：——
• Schmitz-Dumont; ter Horst, Justus Liebigs Annalen der Chemie, vol. 538, p. 270
  作者：Schmitz-Dumont、ter Horst

  DOI：——

  日期：——
• Heat Shock Protein Accumulation Is Upregulated in a Long-Lived Mutant of Caenorhabditis elegans
  作者：G. A. Walker、T. M. White、G. McColl、N. L. Jenkins、S. Babich、E. P. M. Candido、T. E. Johnson、G. J. Lithgow

  DOI：10.1093/gerona/56.7.b281

  日期：2001.7.1

  We present evidence for elevated levels of heat shock protein 16 (HSP16) in an intrinsically thermotolerant, long-lived strain of Caenorhabditis elegans during and after heat stress. Mutation of the age-1 gene, encoding a phosphatidylinositol 3-kinase catalytic subunit, results in both extended life span (Age) and increased intrinsic thermotolerance (Itt) in adult hermaphrodites. We subjected age-synchronous cohorts of worms to lethal and nonlethal thermal stress and observed the accumulation of a small (16-18 kd) heat-shock-specific polypeptide detected by an antibody raised against C. elegans HSP16. Strains carrying the mutation hx546 consistently accumulated HSP16 to higher levels than a wild-type strain. Significantly, overaccumulation of HSP16 in the age-1(hx546) strain following heat was observed throughout the adult life span. A chimeric transgene containing the Escherichia coli beta -galactosidase gene fused to a C. elegans HSP16-41 transcriptional promoter was introduced into wild-type and age-1(hx546) backgrounds. Heat-inducible expression of the transgene was elevated in the age-1(hx546) strain compared with the wild-type strain under a wide variety of heat shock and recovery conditions. These observations are consistent with a model in which Age mutations exhibit thermotolerance and extended life span as a result of elevated levels of molecular chaperones.
• Schmitz -Dumont; ter Horst, Justus Liebigs Annalen der Chemie, vol. 538, p. 270
  作者：Schmitz -Dumont、ter Horst

  DOI：——

  日期：——