4-(4,5-dihydro-3H-benzo[f]azulen-10-ylidene)-1-methylpiperidine

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 4-(4,5-dihydro-3H-benzo[f]azulen-10-ylidene)-1-methylpiperidine
• 化学式: C₂₀H₂₃N
• 分子量: 277.4
• InChiKey: DDPZMNGLIWEWPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS
  申请人：Case Western Reserve University

  公开号：US20140235562A1

  公开（公告）日：2014-08-21

  A method of treating an ocular disorder in a subject includes administering to the subject a therapeutically effective amount of an agent that modulates at least one target in a signaling cascade associated with light induced retinal degeneration, aberrant all-trans-retinal accumulation, and/or generation of reactive oxygen species (ROS).
• SYSTEMS PHARMACOLOGY FOR TREATING OCULAR DISORDERS
  申请人：Case Western Reserve University

  公开号：US20180071285A1

  公开（公告）日：2018-03-15

  A method of treating an ocular disorder in a subject includes administering to the subject subtherapeutic amounts of two or more agents that inhibit and/or blocks the activation of Gs- or Gq-protein coupled receptors or Gs- or Gq-signaling cascade in ocular cells of the subject, and/or activates Gi-protein coupled receptors, which is induced or triggered by light induced all-trans-retinal generation.