(4R)-4-methyl-5-[(3S)-2-oxopentan-3-yl]oxolan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (4R)-4-methyl-5-[(3S)-2-oxopentan-3-yl]oxolan-2-one
• 化学式: C₁₀H₁₆O₃
• 分子量: 184.23
• InChiKey: DTQFJHKSPFDJJG-SXDVZSMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Deuterated Cyclosporine Analogs and Methods of Making the Same
  申请人：Aurinia Pharmaceuticals, Inc.

  公开号：US20140235819A1

  公开（公告）日：2014-08-21

  Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabo-lism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and methods of producing immunosuppression with reduced toxicity using the disclosed cyclosporine derivatives.