2-[(4S,5R)-2-[(1S)-1-amino-2-(4-fluorophenyl)ethyl]-5-naphthalen-2-yloxan-4-yl]acetonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[(4S,5R)-2-[(1S)-1-amino-2-(4-fluorophenyl)ethyl]-5-naphthalen-2-yloxan-4-yl]acetonitrile
• 化学式: C₂₅H₂₅FN₂O
• 分子量: 388.5
• InChiKey: FNNKZGYRUAUKMV-SAORYEJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Compounds and methods of treating ocular disorders
  申请人：Case Western Reserve University

  公开号：US10208049B2

  公开（公告）日：2019-02-19

  A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound.

  一种治疗与视网膜中全反式视网膜清除异常有关的受试者眼部疾病的方法，该方法包括向受试者施用治疗有效量的式伯胺化合物： 其中 R1 是脂肪族和/或芳香族化合物。
• COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS
  申请人：Case Western Reserve University

  公开号：US20140235604A1

  公开（公告）日：2014-08-21

  A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R 1 is an aliphatic and/or aromatic compound.