1-N'-[3-fluoro-4-[2-[7-(hydroxyamino)-7-oxoheptoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-N'-[3-fluoro-4-[2-[7-(hydroxyamino)-7-oxoheptoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• 化学式: C₃₄H₃₄F₂N₄O₇
• 分子量: 648.7
• InChiKey: LIEPQGHACSXIAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  47
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  153
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• HYDROXAMIC ACID COMPOUND CONTAINING QUINOLYL AND PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THIS COMPOUND AND USE THEREOF
  申请人：Beijing Konruns Pharmaceutical Co., Ltd.

  公开号：EP2769976A1

  公开（公告）日：2014-08-27

  Provided in the present invention is a quinolyl-containing hydroxamic acid compound as shown in formula (I), at the same time also disclosed is the preparation method of the compound and the use thereof, and a pharmaceutical composition containing the quinolyl-containing hydroxamic acid compound. Such compounds are inhibitors of protein kinases and/or histone deacetylases, and can be used in the treatment of diseases caused by the abnormal activity of protein kinases and/or histone deacetylases, for example, tumors, etc.

  本发明提供了一种如式（I）所示的含醌羟肟酸化合物，同时还公开了该化合物的制备方法及其用途，以及一种含有该含醌羟肟酸化合物的药物组合物。此类化合物是蛋白激酶和/或组蛋白去乙酰化酶的抑制剂，可用于治疗由蛋白激酶和/或组蛋白去乙酰化酶活性异常引起的疾病，如肿瘤等。