N,N-Dimethyl-3,5-diacetylaniline | 205498-59-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N,N-Dimethyl-3,5-diacetylaniline
• 英文别名: 1-[3-acetyl-5-(dimethylamino)phenyl]ethanone
• CAS: 205498-59-5
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.25
• InChiKey: MGDSYNXHUQPQSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Compounds and methods of use to treat infectious diseases
  申请人：Bukrinsky I. Michael

  公开号：US20060014760A1

  公开（公告）日：2006-01-19

  The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby blocking importation of specific proteins or molecular complex into the nucleus of a cell. The invention encompasses methods of use of such compounds for treatment or prevention of infectious diseases, such as parasitic and viral diseases, including, for example, malaria and acquired immunodeficiency syndrome. The use of the compounds to detect certain specific protein structures which are present in nuclear localization sequences is also taught.

  本发明涉及具有抗感染活性的烷基芳基羰基化合物。该发明的化合物可用于靶向特定的核定位信号，从而阻止特定蛋白质或分子复合物进入细胞核。本发明包括使用这些化合物治疗或预防传染病的方法，如寄生虫和病毒性疾病，包括例如疟疾和获得性免疫缺陷综合症。本发明还教授了使用这些化合物检测核定位序列中存在的某些特定蛋白质结构的方法。
• N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
  申请人：John Varghese

  公开号：US20070213316A1

  公开（公告）日：2007-09-13

  Disclosed are compounds of the formula wherein the variables R N , R C , R 1 , R 25 , R 2 , and R 3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.

  本发明揭示了以下式子的化合物：其中变量RN，RC，R1，R25，R2和R3如本文所定义。这些化合物具有抑制β-分泌酶的活性，因此可用于治疗多种疾病，例如阿尔茨海默病。
• Compounds and Methods Used to Treat Infectious Diseases
  申请人：Bukrinsky Michael I.

  公开号：US20100137566A1

  公开（公告）日：2010-06-03

  The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby blocking importation of specific proteins or molecular complex into the nucleus of a cell. The invention encompasses methods of use of such compounds for treatment or prevention of infectious diseases, such as parasitic and viral diseases, including, for example, malaria and acquired immunodeficiency syndrome. The use of the compounds to detect certain specific protein structures which are present in nuclear localization sequences is also taught.

  本发明涉及具有抗感染活性的烷基芳基羰基化合物。本发明的化合物可用于针对特定的核定位信号，从而阻止特定蛋白质或分子复合物进入细胞核。本发明涵盖了使用这些化合物治疗或预防传染病的方法，例如寄生虫和病毒性疾病，包括疟疾和获得性免疫缺陷综合症。本发明还教导了使用这些化合物检测存在于核定位序列中的某些特定蛋白质结构的方法。
• EP0865434A4
  申请人：——

  公开号：EP0865434A4

  公开（公告）日：1998-09-23
• COMPOUNDS AND METHODS OF USE TO TREAT INFECTIOUS DISEASES
  申请人：THE PICOWER INSTITUTE FOR MEDICAL RESEARCH

  公开号：EP0865434A1

  公开（公告）日：1998-09-23