methyl N-[[2-(diethylamino)quinolin-3-yl]methyl]-N-[[3-(fluoromethyl)-5-(trifluoromethyl)phenyl]methyl]carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: methyl N-[[2-(diethylamino)quinolin-3-yl]methyl]-N-[[3-(fluoromethyl)-5-(trifluoromethyl)phenyl]methyl]carbamate
• 化学式: C₂₅H₂₇F₄N₃O₂
• 分子量: 477.5
• InChiKey: WPBIWSULVHQOHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  45.7
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP1848430B1

  公开（公告）日：2017-08-02
• [EN] PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES D'INHIBITEURS CETP
  申请人：REDDYS LAB LTD DR

  公开号：WO2014128564A2

  公开（公告）日：2014-08-28

  The present application discloses a pharmaceutical composition comprising a class of cholesteryl ester transfer protein (CETP) inhibitors with improved oral bioavailability. The application further discloses compositions comprising a class of CETP inhibitor and at least one surfactant in the form of a solution, suspension, emulsion or a pre-concentrate.