[4-[2-[chloro-[4-[[[2-hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-3-methoxyphenyl]carbamoyl]oxyethyl-methylamino]cyclohexyl] 2-hydroxy-2,2-dithiophen-2-ylacetate;hydrofluoride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [4-[2-[chloro-[4-[[[2-hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-3-methoxyphenyl]carbamoyl]oxyethyl-methylamino]cyclohexyl] 2-hydroxy-2,2-dithiophen-2-ylacetate;hydrofluoride
• 化学式: C39H44ClFN4O9S2
• 分子量: 831.4
• InChiKey: IKMQNVHSSLKZCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.16
• 重原子数：
  56
• 可旋转键数：
  17
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  227
• 氢给体数：
  6
• 氢受体数：
  14

文献信息

• [EN] SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH &bgr;2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES<br/>[FR] SEL DE DÉRIVÉS DE 2-AMINO-1-HYDROXYÉTHYL-8-HYDROXYQUINOLIN-2(1H)-ONE AYANT À LA FOIS L'ACTIVITÉ D'UN AGONISTE DES RÉCEPTEURS &Bgr;2 ADRÉNERGIQUES ET D'UN AGONISTE DES RÉCEPTEURS M3 MUSCARINIQUES.
  申请人：ALMIRALL SA

  公开号：WO2014131851A1

  公开（公告）日：2014-09-04

  The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a hydroxycarboxylic acid, a sulfonic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.

  本发明涉及（i）8-羟基喹啉-2(1H)-酮衍生物和（ii）羟基羧酸、磺酸或磺酰亚胺的结晶加合盐，或其药用可接受的溶剂化合物。
• SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH β2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES
  申请人：ALMIRALL S.A.

  公开号：US20160009698A1

  公开（公告）日：2016-01-14

  The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a hydroxycarboxylic acid, a sulfonic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.

  本发明涉及(i) 8-羟基喹啉-2(1H)-酮衍生物和(ii)羟基羧酸、磺酸或磺酰亚胺的晶体加合物，或其药学上可接受的溶剂化合物。
• SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH 2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES
  申请人：Almirall S.A.

  公开号：EP2961407B1

  公开（公告）日：2018-04-11
• SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH 2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES
  申请人：Almirall S.A.

  公开号：EP2961407A1

  公开（公告）日：2016-01-06
• US9562039B2
  申请人：——

  公开号：US9562039B2

  公开（公告）日：2017-02-07