(E,2S)-4-amino-4-(3-bromophenyl)-1,1,1,3-tetrafluorobut-3-en-2-ol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醇
• 英文名称: (E,2S)-4-amino-4-(3-bromophenyl)-1,1,1,3-tetrafluorobut-3-en-2-ol
• 化学式: C₁₀H₈BrF₄NO
• 分子量: 314.07
• InChiKey: RZBAHRJWDNOGLI-FLOXNTQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE<br/>[FR] COMPOSÉS PERFLUORÉS 5,6-DIHYDRO-4H-1,3-OXAZINE-2-AMINE SUBSTITUÉS EN TANT QU'INHIBITEURS DE LA BÊTA-SÉCRÉTASE ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：AMGEN INC

  公开号：WO2014134341A1

  公开（公告）日：2014-09-04

  The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I): wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.