(1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine;sulfuric acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine;sulfuric acid
• 化学式: C24H33N5O5S
• 分子量: 503.6
• InChiKey: BCPCHMKBPZWBTG-ZCVIPUSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  172
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Topical compositions and methods of treatment of topical disorders
  申请人：PeriTech Pharma Ltd.

  公开号：US10085994B2

  公开（公告）日：2018-10-02

  A topical composition includes at least one film forming ingredient; at least one surfactant; at least one non-polar volatile siloxane solvent; at least 15% (w/w) water; and a therapeutically effective concentration of at least one pharmaceutical agent, wherein the composition is sufficiently designed to dry within 60 seconds after application to a body surface to form a dried composition, and wherein the dried composition forms: a flexible film, wherein the flexible film closely follows irregularities of the body surface as well as movement of the body surface, and (ii) a durable film, wherein the durable film does not crack or flake off and remains intact for more than 12 hours giving release of the pharmaceutical agent for an extended period of time.

  一种外用组合物包括至少一种成膜成分；至少一种表面活性剂；至少一种非极性挥发性硅氧烷溶剂；至少 15%（重量比）的水；以及至少一种药剂的治疗有效浓度，其中该组合物被充分设计成在涂抹到身体表面后 60 秒内干燥，以形成干燥的组合物，并且其中干燥的组合物形成：(i) 柔性膜，其中柔性膜紧贴身体表面的不规则部位以及身体表面的移动；以及 (ii) 耐用膜，其中耐用膜不会开裂或剥落，并保持完好：柔性薄膜，其中柔性薄膜紧贴身体表面的不规则部位以及身体表面的移动；以及 (ii) 持久薄膜，其中持久薄膜不会开裂或剥落，并在 12 小时以上保持完好无损，使药剂在更长的时间内释放。
• TOPICAL COMPOSITIONS AND METHODS OF TREATMENT OF TOPICAL DISORDERS
  申请人：Peritech Pharma Ltd.

  公开号：EP2968133A2

  公开（公告）日：2016-01-20
• US20140255521A1
  申请人：——

  公开号：US20140255521A1

  公开（公告）日：2014-09-11
• US20140255522A1
  申请人：——

  公开号：US20140255522A1

  公开（公告）日：2014-09-11
• METHODS OF TREATMENT OF ANORECTAL AND GENITAL DISORDERS
  申请人：PeriTech Pharma Ltd.

  公开号：US20180344743A1

  公开（公告）日：2018-12-06

  A topical anorectal or genital composition includes at least one film forming ingredient; at least one surfactant; at least one non-polar volatile siloxane solvent; at least 15% (w/w) water; and a therapeutically effective concentration of at least one pharmaceutical agent, wherein the composition is sufficiently designed to dry within 60 seconds after application to the anorectal or genital surface to form a dried composition, and wherein the dried composition forms: a flexible film, wherein the flexible film closely follows irregularities of the body surface as well as movement of the body surface, and (ii) a durable film, wherein the durable film does not crack or flake off and remains intact for more than 12 hours giving release of the pharmaceutical agent for an extended period of time.