2-(furan-2-yl)-4-(pyridin-2-yl)-1-(thiophen-2-yl)butane-1,4-dione | 1365537-27-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(furan-2-yl)-4-(pyridin-2-yl)-1-(thiophen-2-yl)butane-1,4-dione
• 英文别名: 2-(Furan-2-yl)-4-pyridin-2-yl-1-thiophen-2-ylbutane-1,4-dione；2-(furan-2-yl)-4-pyridin-2-yl-1-thiophen-2-ylbutane-1,4-dione
• CAS: 1365537-27-4
• 化学式: C₁₇H₁₃NO₃S
• 分子量: 311.361
• InChiKey: WOLZPOUCKGGAQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  88.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-噻吩甲醛 、 3-(furan-2-yl)-1-(pyridin-2-yl)prop-2-en-1-one 在 3,3'-(1,4-phenylenebis(methylene))bis(5-(2-hydroxyethyl)-4-methylthiazol-3-ium) bromide 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙醇 为溶剂， 反应 13.0h， 以81%的产率得到2-(furan-2-yl)-4-(pyridin-2-yl)-1-(thiophen-2-yl)butane-1,4-dione
  参考文献：
  名称：

  An efficient synthesis of 2-aryl-1,4-diketones via hydroacylation of enones

  摘要：

  An improved method has been developed for the hydroacylation of enones with aldehydes employing bis-5-(2-hydroxyethyl)-1,3-thiazolium bromide/Et3N system to afford the corresponding 1,4-diketones in good yields. This method is effective for the preparation of 1,4-diketones from both aromatic and aliphatic aldehydes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.104

文献信息

• An efficient synthesis of 2-aryl-1,4-diketones via hydroacylation of enones
  作者：P. Lakshmi Reddy、K. Praveen Kumar、S. Satyanarayana、R. Narender、B.V. Subba Reddy

  DOI：10.1016/j.tetlet.2011.12.104

  日期：2012.3

  An improved method has been developed for the hydroacylation of enones with aldehydes employing bis-5-(2-hydroxyethyl)-1,3-thiazolium bromide/Et3N system to afford the corresponding 1,4-diketones in good yields. This method is effective for the preparation of 1,4-diketones from both aromatic and aliphatic aldehydes. (C) 2011 Elsevier Ltd. All rights reserved.