5-((1H-imidazol-1-yl)methyl)-2-bromothiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-((1H-imidazol-1-yl)methyl)-2-bromothiazole
• 英文别名: 2-bromo-5-(imidazol-1-ylmethyl)-1,3-thiazole
• 化学式: C₇H₆BrN₃S
• 分子量: 244.11
• InChiKey: KJPBNNMZTAAZTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-溴-5-溴甲基噻唑 、 咪唑 、 potassium carbonate 在 Brine 、 乙酸乙酯 作用下， 以 二甲基亚砜 为溶剂， 反应 16.0h， 以to yield 306.6 nag (42%) of the desired product的产率得到
  参考文献：
  名称：

  Methods, Compounds, and Compositions for the Treatment of Angiotensin-Related Diseases

  摘要：

  本发明涉及小分子非肽化合物，以及用于治疗与肾素-血管紧张素系统相关的疾病和障碍的方法和组合物，包括心血管疾病、代谢性疾病、胃肠道疾病、肾脏疾病、炎症/自身免疫性疾病、神经系统疾病、骨髓疾病和癌症。

  公开号：

  US20160016946A1

文献信息

• [EN] METHODS, COMPOUNDS, AND COMPOSITIONS FOR THE TREATMENT OF ANGIOTENSIN-RELATED DISEASES<br/>[FR] PROCÉDÉS, COMPOSÉS ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES LIÉES À L'ANGIOTENSINE
  申请人：UNIV SOUTHERN CALIFORNIA

  公开号：WO2014145331A1

  公开（公告）日：2014-09-18

  Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer.

  揭示了小分子非肽化合物，以及用于治疗与肾素相关的疾病和紊乱的方法和组合物，包括心血管疾病、代谢性疾病、消化系统疾病、肾脏疾病、炎症/自身免疫疾病、神经系统疾病、骨髓疾病和癌症。
• COMPOUNDS FOR THE TREATMENT OF MUSCULOSKELETAL DISEASES
  申请人：University Of Southern California, USC Stevens

  公开号：EP3935944A1

  公开（公告）日：2022-01-12

  Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer. In particular, the invention provides compounds, methods and compositions for the treatment of metabolic diseases and disorders, such as diabetes mellitus, diabetes-related cardiovascular diorders, diabetes-related dermal ulcerations, diabetes related hypertension, and diabetes-related ophthalmic diseases.

  本发明公开了用于治疗血管紧张素相关疾病和紊乱（包括心血管疾病、代谢性疾病、胃肠道疾病、肾脏疾病、炎症/自身免疫性疾病、神经系统疾病、骨髓疾病和癌症）的小分子非肽化合物、方法和组合物。特别是，本发明提供了用于治疗代谢性疾病和紊乱的化合物、方法和组合物，如糖尿病、糖尿病相关心血管疾病、糖尿病相关皮肤溃疡、糖尿病相关高血压和糖尿病相关眼科疾病。
• Methods, compounds, and compositions for the treatment of angiotensin-related diseases
  申请人：University of Southern California

  公开号：US10301298B2

  公开（公告）日：2019-05-28

  Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer. In particular, the invention provides compounds, methods and compositions for the treatment of metabolic diseases and disorders, such as diabetes mellitus, diabetes-related cardiovascular disorders, diabetes-related dermal ulcerations, diabetes related hypertension, and diabetes-related ophthalmic diseases.

  本发明公开了用于治疗血管紧张素相关疾病和紊乱（包括心血管疾病、代谢性疾病、胃肠道疾病、肾脏疾病、炎症/自身免疫性疾病、神经系统疾病、骨髓疾病和癌症）的小分子非肽化合物、方法和组合物。特别是，本发明提供了用于治疗代谢性疾病和紊乱的化合物、方法和组合物，如糖尿病、糖尿病相关心血管疾病、糖尿病相关皮肤溃疡、糖尿病相关高血压和糖尿病相关眼科疾病。
• METHODS, COMPOUNDS, AND COMPOSITIONS FOR THE TREATMENT OF ANGIOTENSIN-RELATED DISEASES
  申请人：University Of Southern California

  公开号：EP2967049A1

  公开（公告）日：2016-01-20
• US9732074B2
  申请人：——

  公开号：US9732074B2

  公开（公告）日：2017-08-15